Umberto Zottich , Isadora Sousa de Oliveira , Isabela Gobbo Fereira , Felipe Augusto Cerni , Bordon Karla de Castro Figueiredo , Eliane Candiani Arantes , Valdirene Moreira Gomes , Germana Bueno Dias , Manuela Berto Pucca
{"title":"Antifungal activity of Rhopalurus crassicauda venom against Candida spp.","authors":"Umberto Zottich , Isadora Sousa de Oliveira , Isabela Gobbo Fereira , Felipe Augusto Cerni , Bordon Karla de Castro Figueiredo , Eliane Candiani Arantes , Valdirene Moreira Gomes , Germana Bueno Dias , Manuela Berto Pucca","doi":"10.1016/j.toxcx.2022.100120","DOIUrl":null,"url":null,"abstract":"<div><p>Fungal infections are becoming a serious problem of human diseases, being one of the most important fungal pathogens the yeast of the genus <em>Candida</em>. So far, fungal infection treatment faces different challenges, including the limited number of therapeutic drugs. Scorpions are known to be a valuable source of biologically active molecules, especially of peptide-derived molecules with a variety of biological effects and useful, lead compounds for drugs development. Here, we pioneer described the antifungal effect of venom, mucus, and the major toxin (Rc1) from <em>Rhopalurus crassicauda</em> scorpion. These results support the potential for Rc1 to be further investigated as a novel antifungal therapeutic to treat <em>Candida</em> infections.</p></div>","PeriodicalId":37124,"journal":{"name":"Toxicon: X","volume":null,"pages":null},"PeriodicalIF":3.6000,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590171022000303/pdfft?md5=c78539d4b6e34e3c2da98db660c8d54d&pid=1-s2.0-S2590171022000303-main.pdf","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Toxicon: X","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2590171022000303","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"TOXICOLOGY","Score":null,"Total":0}
引用次数: 1
Abstract
Fungal infections are becoming a serious problem of human diseases, being one of the most important fungal pathogens the yeast of the genus Candida. So far, fungal infection treatment faces different challenges, including the limited number of therapeutic drugs. Scorpions are known to be a valuable source of biologically active molecules, especially of peptide-derived molecules with a variety of biological effects and useful, lead compounds for drugs development. Here, we pioneer described the antifungal effect of venom, mucus, and the major toxin (Rc1) from Rhopalurus crassicauda scorpion. These results support the potential for Rc1 to be further investigated as a novel antifungal therapeutic to treat Candida infections.
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