Antifungal activity of Rhopalurus crassicauda venom against Candida spp.

IF 3.6 Q2 TOXICOLOGY

Toxicon: X Pub Date : 2022-06-01 DOI:10.1016/j.toxcx.2022.100120

Umberto Zottich , Isadora Sousa de Oliveira , Isabela Gobbo Fereira , Felipe Augusto Cerni , Bordon Karla de Castro Figueiredo , Eliane Candiani Arantes , Valdirene Moreira Gomes , Germana Bueno Dias , Manuela Berto Pucca

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引用次数: 1

Abstract

Fungal infections are becoming a serious problem of human diseases, being one of the most important fungal pathogens the yeast of the genus Candida. So far, fungal infection treatment faces different challenges, including the limited number of therapeutic drugs. Scorpions are known to be a valuable source of biologically active molecules, especially of peptide-derived molecules with a variety of biological effects and useful, lead compounds for drugs development. Here, we pioneer described the antifungal effect of venom, mucus, and the major toxin (Rc1) from Rhopalurus crassicauda scorpion. These results support the potential for Rc1 to be further investigated as a novel antifungal therapeutic to treat Candida infections.

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荆芥毒对念珠菌的抗真菌活性研究。

念珠菌属酵母菌是最重要的真菌病原体之一，真菌感染已成为人类疾病的一个严重问题。到目前为止，真菌感染的治疗面临着不同的挑战，包括治疗药物的数量有限。蝎子被认为是生物活性分子的宝贵来源，特别是具有多种生物效应的肽衍生分子和有用的药物开发先导化合物。本文首先研究了天蝎毒液、黏液和主要毒素(Rc1)的抗真菌作用。这些结果支持了Rc1作为一种治疗念珠菌感染的新型抗真菌药物的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Toxicon: X Pharmacology, Toxicology and Pharmaceutics-Toxicology

CiteScore

6.50

自引率

0.00%

发文量

审稿时长

14 weeks