Successful treatment of calciphylaxis with bisphosphonates in kidney transplant recipients suffering from secondary hyperparathyroidism: A report of two cases

Q4 Medicine

Transplantation Reports Pub Date : 2020-12-01 DOI:10.1016/j.tpr.2020.100068

Ho-Kwan Sin, Ping-Nam Wong, Kin-Yee Lo, Man-Wai Lo, Shuk-Fan Chan, Kwok-Chi Lo, Yuk-Yi Wong, Lo-Yi Ho, Wing-Tung Kwok, Kai-Chun Chan, Andrew Kui-Man Wong, Siu-Ka Mak

引用次数: 0

Abstract

Background

The optimal management of calciphylaxis in kidney transplant recipients (KTRs) is uncertain.

Case presentation

We report 2 cases of refractory calciphylaxis in KTRs who suffered from persistent secondary hyperparathyroidism. They failed initial therapy with sodium thiosulphate but responded to treatment with bisphosphonates. No adverse events were noted with bisphosphonate therapy.

Conclusion

Bisphosphonates appear to be an effective therapy for KTRs with calciphylaxis who cannot tolerate or respond poorly to STS, particularly if they have persistent hyperparathyroidism post-transplantation.

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双膦酸盐成功治疗肾移植受者继发性甲状旁腺功能亢进的钙化反应:两例报告

背景肾移植受者(KTRs)的最佳钙化治疗尚不确定。我们报告2例难治性钙化反应的KTRs谁遭受持续性继发性甲状旁腺功能亢进。他们最初用硫代硫酸钠治疗失败，但对双膦酸盐治疗有反应。双膦酸盐治疗未发现不良事件。结论对于不能耐受或对STS反应不良的伴有钙化反应的KTRs，特别是移植后持续性甲状旁腺功能亢进患者，双膦酸盐似乎是一种有效的治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Transplantation Reports Medicine-Transplantation

CiteScore

0.60

自引率

0.00%

发文量

审稿时长

101 days

期刊介绍： To provide to national and regional audiences experiences unique to them or confirming of broader concepts originating in large controlled trials. All aspects of organ, tissue and cell transplantation clinically and experimentally. Transplantation Reports will provide in-depth representation of emerging preclinical, impactful and clinical experiences. -Original basic or clinical science articles that represent initial limited experiences as preliminary reports. -Clinical trials of therapies previously well documented in large trials but now tested in limited, special, ethnic or clinically unique patient populations. -Case studies that confirm prior reports but have occurred in patients displaying unique clinical characteristics such as ethnicities or rarely associated co-morbidities. Transplantation Reports offers these benefits: -Fast and fair peer review -Rapid, article-based publication -Unrivalled visibility and exposure for your research -Immediate, free and permanent access to your paper on Science Direct -Immediately citable using the article DOI