Synthesis and Biological Evaluation of (E)-N’-Benzylidene-7-methyl-2-propyl-1H-benzo[d] imidazole-5-carbohydrazides as Antioxidant, Anti-inflammatory and Analgesic agents

IF 1.3 3区化学 Q3 CHEMISTRY, ORGANIC

Heterocyclic Communications Pub Date : 2019-01-01 DOI:10.1515/hc-2019-0009

Ramamurthy Katikireddy, Ramu Kakkerla, M. Krishna, G. Durgaiah, Y. Reddy, M. Satyanarayana

引用次数: 12

Abstract

Abstract (E)-N’-Benzylidene-7-methyl-2-propyl-1H-benzo [d]imidazole-5-carbohydrazides (5a-r) have been synthesized from 7-methyl-2-propyl-1H-benzo[d]imidazole-5-carbohydrazide (3) by condensing with different aromatic aldehydes (4a-r). Title compounds (5a-r) were evaluated for in vitro antioxidant activity and based on their potential for antioxidant property, selected compounds 5d and 5m-p were screened for in vivo anti-inflammatory and analgesic activity. The results indicate that the compound 5o and 5p are effective against anti-inflammatory and analgesic activity. The biological data was further supported by molecular docking studies, which revealed the binding pattern and the affinity of the molecules in the active site of COX-2.

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(E)-N′-苄基-7-甲基-2-丙基- 1h -苯并咪唑-5-碳腙类抗氧化、抗炎、镇痛药物的合成及生物学评价

摘要以7-甲基-2-丙基- 1h -苯并[d]咪唑-5-碳肼(3)为原料，与不同芳香醛(4a-r)缩合，合成了(E)-N ' -苄基-7-甲基-2-丙基- 1h -苯并[d]咪唑-5-碳肼(5a-r)。对标题化合物(5a-r)进行体外抗氧化活性评估，并根据其抗氧化性能的潜力，筛选出化合物5d和5m-p进行体内抗炎和镇痛活性筛选。结果表明，化合物50和5p具有抗炎、镇痛作用。分子对接研究进一步支持了生物学数据，揭示了COX-2活性位点分子的结合模式和亲和力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Heterocyclic Communications 化学-有机化学

CiteScore

3.80

自引率

4.30%

发文量

审稿时长

1.4 months

期刊介绍： Heterocyclic Communications (HC) is a bimonthly, peer-reviewed journal publishing preliminary communications, research articles, and reviews on significant developments in all phases of heterocyclic chemistry, including general synthesis, natural products, computational analysis, considerable biological activity and inorganic ring systems. Clear presentation of experimental and computational data is strongly emphasized. Heterocyclic chemistry is a rapidly growing field. By some estimates original research papers in heterocyclic chemistry have increased to more than 60% of the current organic chemistry literature published. This explosive growth is even greater when considering heterocyclic research published in materials science, physical, biophysical, analytical, bioorganic, pharmaceutical, medicinal and natural products journals. There is a need, therefore, for a journal dedicated explicitly to heterocyclic chemistry and the properties of heterocyclic compounds.