A Review on the Synthesis and Pharmacological Activity of Heterocyclic Compounds

Current physical chemistry Pub Date : 2022-10-21 DOI:10.2174/1877946813666221021144829

J. Baranwal, Smriti Kushwaha, Swastika Singh, Archana Jyoti

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引用次数: 3

Abstract

Biologically active compounds play a very important role in our daily life. Almost all the biologically active compounds contain heteroatoms and among these a major portion are heterocycles. Heterocycles are a significant component in drug development programs. Drugs containing a heterocyclic moiety are highly valued resources in the fight against human and animal diseases and disorders. Some of these compounds are utilized as anticonvulsants antivirals, anti-inflammatory, and central vasodilators, while others are used as nontherapeutic anthelmintics, diuretics, anti-hypertensives, uricosurics, fungicides, bactericides, herbicides. In this review, we have discussed the chemistry of heterocyclic compounds such as Quinoxaline, Triazole, Pyrimidine, Pyridine, Oxadiazole, Thiazole, Indole, and Azepine. Besides some of their recent synthetic methodologies, their pharmaceutical importance is also discussed. Undoubtedly, the contents of this review will motivate readers to do more novel work in this area which will accelerate the journey towards the exploration of the pharmacological activity of heterocyclic compounds.

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杂环类化合物的合成及其药理活性研究进展

生物活性化合物在我们的日常生活中起着非常重要的作用。几乎所有的生物活性化合物都含有杂原子，其中大部分是杂环。杂环是药物开发计划的重要组成部分。含有杂环部分的药物在对抗人类和动物疾病和障碍方面是非常有价值的资源。这些化合物中的一些被用作抗惊厥剂、抗病毒药物、抗炎药和中枢血管舒张剂，而另一些则被用作非治疗性驱虫药、利尿剂、抗高血压药、尿酸药物、杀菌剂、杀菌剂和除草剂。在这篇综述中，我们讨论了杂环化合物的化学，如喹喔啉、三唑、嘧啶、吡啶、恶二唑、噻唑、吲哚和阿泽平。除了最近的一些合成方法外，还讨论了它们在药物方面的重要性。毫无疑问，这篇综述的内容将激励读者在这一领域做更多的新颖工作，这将加速杂环化合物药理活性的探索之旅。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Current physical chemistry

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