Tenofovir Induced Acute Kidney Injury and Severe Anemia: A Case Series of Four Patients

Abstract

We report four cases of atypical acute kidney injury (AKI) associated with the used of Tenofovir (TDF). Elevated creatinine, normoglycemic glycosuria with unusual high proteinuria, high serum phosphate and severe anemia were observed. After withdrawal of TDF, glomerular filtration rate (GFR) and hemoglobin level increase in all the patients, but only one patient have a complete remission. Clinician should be aware of this atypical TDF induced AKI presentation with end stage Kidney Disease characteristics.