Determination of total antioxidant capacity in patients with bladder cancer and its correlation with the results of pathology

Abstract

Introduction: The accumulative consequence of all antioxidants that exist in the blood and body fluids is called total antioxidant capacity (TAOC). The major objective of this investigation is to determine the correlation between TAOC and pathology results in patients with non-muscle invasive bladder cancer (NMIBC). Materials and Methods: Based on the cross-sectional method, 35 patients with NMIBC and 35 controls (healthy characters) were studied. Biochemical and haematological variables were achieved and noted for each individual. Two blood samples (n = 5 ml) from each patient were obtained and analysed using Trolox standard immunoassay kit. Three groups were made according to the pathology results. The significance level was set at P ≤ 0.05. Results: There were not any significant differences (P = 0.12) between the mean age of patients and controls (60.7 vs. 59.5 years old) correspondingly. The mean value of TAOC (μmol/L) was significantly (P = 0.005) lower in patients when compared to controls (24.5 μmol/L vs. 94 μmol/L), respectively. In patients with NMIBC, sodium, magnesium, calcium, albumin, MCH, MCHC, VHCO3, haemoglobin, haematocrit and lymph were lower than the normal range. Blood sugar, creatinine, prothrombin time and white blood cells were higher than the normal range. The mean TAOC was as follows: papillary cell carcinoma (26.3 μmol/L), radical cystectomy (19 μmol/L) and high-grade bladder cancer (15.9 μmol/L). Conclusion: As deregulation of reactive oxygen species and antioxidant defence is two important components, in this study, there was high variation in TAOC according to pathology results. Combing individual TAOC and pathology results might be able to contribute to the advanced management of NMIBC. Further studies in this direction seem to be advantageous.