Phytochemicals, Antioxidant, and Chemopreventive Potential of Tamarix Indica Leaf Extracts

IF 1.2 Q4 PHARMACOLOGY & PHARMACY

Journal of Herbs, Spices and Medicinal Plants Pub Date : 2021-12-28 DOI:10.1080/10496475.2021.2015506

S. Paul, K. Naher, Sanzida Yeasmin, Rabindra Nath Acharrya, M. Golder, K. S. Ahmed, Hemayet Hossain, Shrabanti Dev, A. Das

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引用次数: 1

Abstract

ABSTRACT Ethanolic leaf extract of Tamarix indica was evaluated for the antioxidant and anticancer activities and toxicological profiles. The flavonoid, phenolic, and tannin contents of leaves were estimated as 5.3068 mg of QE g−1, 8.786 mg of GAE g−1, and 8.5216 mg of GAE g−1, respectively. In DPPH scavenging assay, T. indica leaves’ extract had an IC50 value of 74.38 μg mL−1. HPLC-DAD analysis identified catechin hydrate, vanillic acid, rutin hydrate, p-coumaric acid, and myricetin in different concentrations. In brine shrimp lethality bioassay, the IC50 value of the extract was 19.928 µg mL−1. Chemopreventive activity was evaluated using DMBA/croton oil-induced skin cancinogenic model mice. Oral treatment of the extract at different doses reduced the size, number, yield, and burden of tumor in skin carcinogenic mice. Natural antioxidants GSH and SOD increased with extract treatment. Additionally, reduction in blood bilirubin, SGPT, and SGOT levels were observed in extract treated mice. In acute toxicity study, no mortality was observed in mice justifying the safety of the extract.

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柽柳叶提取物的植物化学、抗氧化和化学预防作用

摘要对柽柳叶乙醇提取物的抗氧化、抗癌活性和毒理学特性进行了研究。叶片中黄酮类、酚类和单宁含量分别为5.3068 mg QE g−1、8.786 mg GAE g−1和8.5216 mg GAE g−1。在DPPH清除实验中，籼米叶提取物的IC50值为74.38 μ mL−1。HPLC-DAD分析鉴定出不同浓度的水合儿茶素、香草酸、水合芦丁、对香豆酸和杨梅素。在盐水对虾致死生物测定中，该提取物的IC50值为19.928µg mL−1。采用DMBA/巴豆油致皮肤癌变模型小鼠，评价其化学预防作用。口服不同剂量的提取物可降低皮肤癌小鼠肿瘤的大小、数量、产量和负荷。天然抗氧化剂GSH和SOD随提取物处理增加。此外，在提取物处理的小鼠中，观察到血胆红素、SGPT和SGOT水平降低。在急性毒性研究中，未观察到小鼠死亡，证明了提取物的安全性。

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来源期刊

Journal of Herbs, Spices and Medicinal Plants Medicine-Complementary and Alternative Medicine

CiteScore

3.00

自引率

0.00%

发文量

期刊介绍： The Journal of Herbs, Spices & Medicinal Plants is an essential reference filled with recent research and other valuable information associated with herbs, spices, and medicinal plants. The Journal serves as a focus point through which investigators and others may publish material of importance to the production, marketing, and utilization of these plants and associated extracts. The journal covers the following topics: growth, development, horticulture, ecology, physiology, genetics, chemistry, and economics. Original articles, review articles, and book reviews provide information of interest to an international audience of researchers, teachers, technicians, and managers involved with production and/or marketing of herbs, spices, and medicinal plants. Managers of food companies, food processing facilities, medical research laboratories, government agencies, and others interested in new chemicals, food additives, international trade, patents, and other items can easily review new findings. The Journal of Herbs, Spices & Medicinal Plants is a forum in which recent research and other information associated with herbs, spices, and medicinal plants is shared. The Journal represents a centralized database accessible by investigators within the international community that work with or have an interest in herbs, spices, and medicinal plants.