Effect of Amygdalin on the treatment and recurrence of endometriosis in an experimental rat study

IF 0.2 4区生物学 Q4 BIOLOGY

Periodicum Biologorum Pub Date : 2017-09-30 DOI:10.18054/PB.V119I3.4767

H. Dogru, Çiğdem Kunt Işgüder, A. Arici, Asker Zeki Özsoy, I. Delibas, B. Çakmak

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引用次数: 8

Abstract

Background: Endometriosis is an aggressive disorder and associated with infertility, pelvic pain and intra-abdominal adhesions in women of reproductive age. Women with endometriosis has the potential risk of recurrence ranging from 21.5% in two years to 50% in five years after recovery period. Therefore, there is a certain requirement for new drugs as an alternative therapy to the current ones. Aim: The aim of the present study is to compare the effects of amygdalin and leuprolide acetate on endometriosis development and recurrence in rats. Study Design: Animal experiment Methods: A total of 30 adult female rats were enrolled. Induction of endometriosis was performed by implanting endometriotic focci on the peritoneal side of the abdominal wall. Before amygdalin or leuprolide acetate treatment one of the implant was removed for histopathological analysis, and rats were randomly divided into three groups. Saline (Group 1), amygdalin (Group 2), and leuprolide acetate (Group 3) were administered for three weeks. After treatment, one of the remaining three implants was excised for histopathological evaluation, and all treatments were terminated. Estradiol was given after the estradiol induction for the recurrence of endometriosis. Rest of the implanted tissues were removed, then all rats were euthanised. The implant volumes, histopathological injury and fibrosis levels were observed. Results: The endometriotic foci volumes in Group 2 and Group 3 were significantly lower than in Group 1 (p = 0.001, p = 0.002, respectively). The histopathological injury scores and fibrosis levels were not significantly different among the groups (p > 0.05). Conclusion: The present study showed that amygdalin has an evident effect in the treatment of endometriosis.

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杏仁核对大鼠子宫内膜异位症治疗和复发的影响

背景：子宫内膜异位症是一种侵袭性疾病，与育龄妇女不孕、盆腔疼痛和腹腔粘连有关。患有子宫内膜异位症的女性在恢复期后两年内复发的潜在风险为21.5%，五年内复发的风险为50%。因此，对新药作为现有药物的替代疗法有一定的要求。目的：比较苦杏仁苷和醋酸亮丙瑞林对大鼠子宫内膜异位症发生和复发的影响。研究设计：动物实验方法：共招募30只成年雌性大鼠。通过在腹壁腹膜侧植入子宫内膜异位病灶来诱导子宫内膜异位症。在杏仁核或醋酸亮丙瑞林治疗之前，移除其中一个植入物进行组织病理学分析，并将大鼠随机分为三组。生理盐水（第1组）、苦杏仁苷（第2组）和醋酸亮丙瑞林（第3组）给药三周。治疗后，切除其余三个植入物中的一个进行组织病理学评估，并终止所有治疗。雌二醇诱导后给予雌二醇治疗子宫内膜异位症复发。移除植入的其余组织，然后对所有大鼠实施安乐死。观察植入物体积、组织病理学损伤和纤维化水平。结果：第2组和第3组的子宫内膜异位灶体积显著低于第1组（p分别为0.001和0.002）。结论：苦杏仁苷治疗子宫内膜异位症疗效显著。

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来源期刊

Periodicum Biologorum 生物-生物学

CiteScore

0.80

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge.