Role of lowered level of serum vitamin D on diabetic foot ulcer and its possible pathomechanism: A systematic review, meta-analysis, and meta-regression

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-08-23 DOI:10.1016/j.deman.2023.100175

Muhammad Iqhrammullah , Teuku Fais Duta , Meulu Alina , Intan Qanita , Muhammad Alif Naufal , Najlaika Henira , Ghina Tsurayya , Raisha Fathima , Arita Yuda Katiara Rizki , Shakira Amirah

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引用次数: 1

Abstract

Aim

To investigate the association between serum vitamin D (SVD) level and DFU development and to emphasize the involved pathomechanism.

Methods

The search was performed on 12 databases for literature published until 10 March 2023. The protocol has been registered on PROSPERO (CRD42023415744). The selection for the included records followed PRISMA framework. Meta-analyses using random effects model were performed and the data were presented as SMD and 95% CI. Meta-regression was performed to identify factors contributing to the heterogeneity in the pooled analysis.

Results

Twenty-one studies were included in the systematic review with a total number of patients reaching 9,570. Of which, as many as 18 studies were eligible for the meta-analysis. The SDV level is significantly lower in DFU group (p-total=0.0037; SMD= -1.2758; [95% CI: -2.0786 to -0.4730]). Based on the meta-regression, age, study location (based on the continent), and total cholesterol level contribute to the high heterogeneity (p<0.01). In the pooled analysis, inflammatory markers such as serum levels of CRP (n = 4), ESR (n = 3), IL-6 (n = 3), and IL-8 (n = 2) are found significantly higher in DFU group at p<0.01.

Conclusion

Lowered SVD level is associated with DFU, where the pathomechanism for this relationship might involve inflammation and infection susceptibility.

查看原文本刊更多论文

血清维生素D水平降低在糖尿病足溃疡中的作用及其可能的病理机制：系统综述、荟萃分析和元回归

目的探讨血清维生素D (SVD)水平与DFU发生的关系，并强调其病理机制。方法在12个数据库中检索截至2023年3月10日发表的文献。该协议已在PROSPERO上注册(CRD42023415744)。入选记录的选择遵循PRISMA框架。采用随机效应模型进行meta分析，数据以SMD和95% CI表示。荟萃回归分析确定了在合并分析中导致异质性的因素。结果系统评价纳入21项研究，共纳入9570例患者。其中，多达18项研究符合荟萃分析的条件。DFU组SDV水平显著降低(p-total=0.0037;SMD = -1.2758;[95% CI: -2.0786 ~ -0.4730])。基于meta回归，年龄、研究地点(以大陆为基础)和总胆固醇水平导致高异质性(p<0.01)。合并分析发现，DFU组患者血清CRP (n = 4)、ESR (n = 3)、IL-6 (n = 3)、IL-8 (n = 2)等炎症标志物水平显著升高(p < 0.01)。结论SVD水平降低与DFU相关，其病理机制可能与炎症和感染易感性有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.