P.26 Liver Transglutaminase 2 Level Comparison Among Different Dietary Interventions

Abstract

Purpose/Background/Objectives: Tissue transglutaminase (TG2) is a highly expressed protein especially in endothelial cells. TG2 has several functions including transamidation activity which is important in several processes such as extracellular matrix remodeling [1]. TG2 activity takes place in aortic stiffness regulation and atherosclerotic plaque formation [2]. One of the most effective implementation for atheroprone state and general cardiovascular health is calorie restriction (CR). In addition, lipid accumulation and subsequent metabolic disorders can be regulated by CR and longer lifespan can be achieved [3]. In this study we aimed to determine the effect of different CR application types on liver TG2 levels of female mice fed up to 82 weeks old age.