Bacteria: our ally in the fight against cancer

B. Kushwaha, Manish Charan
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Abstract

Cancer heterogeneity and development of resistance is the main limiting factor for the management and treatment of the disease. However, major technological innovations in precision medicine and immunebased therapies have renewed faith in having a cure for different types of cancers. Classical cancer treatment options include chemotherapy, radiotherapy, and immunotherapy. Emergence of novel tumor targeting bacteria could open up new therapeutic avenues. Bacteriotherapy alone or in conjunction with classical cancer therapies has given promising results on local tumor regression and distant metastasis. Moreover, bacteria exhibit direct anti-cancer effects that subsequently aid in the activation of innate and adaptive anti-tumor immune responses. Overall, genetically reprogrammed bacterial vectors holds great potential for the specific targeting of cancers as delivery vehicles. In this review article, we have reviewed the therapeutic potential of bacteriotherapy as monotherapy or combination therapy and discussed its benefits, challenges, and future directions.
细菌:我们对抗癌症的盟友
肿瘤的异质性和耐药的发展是该疾病管理和治疗的主要限制因素。然而,精准医疗和免疫疗法方面的重大技术创新让人们重新燃起了治愈不同类型癌症的信心。经典的癌症治疗方案包括化疗、放疗和免疫疗法。新型肿瘤靶向细菌的出现可能开辟新的治疗途径。细菌治疗或联合经典癌症治疗在局部肿瘤消退和远处转移方面取得了令人鼓舞的结果。此外,细菌表现出直接的抗癌作用,随后有助于激活先天和适应性抗肿瘤免疫反应。总的来说,基因重编程的细菌载体作为递送载体具有很大的潜力,可以针对癌症进行特异性靶向。在这篇综述文章中,我们回顾了细菌治疗作为单一治疗或联合治疗的治疗潜力,并讨论了其优点,挑战和未来的发展方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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