Variation of Total Antioxidant Activity in Young People with Non-Lesional Cardiac Arrhythmias

M. Beznă, C. Pisoschi, M. Beznă, S. Dănoiu, C. Negroiu, P. R. Melinte
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引用次数: 1

Abstract

Total antioxidant activity status (TAS) represents the body's response to oxidative stress, important in the pathogenic assessment of oxidations. Aim: To determine TAS variations in young subjects, with non-lesional cardiac arrhythmias, with/without dyslipidemia and to assess the risk of lipid oxidation. Patients and methods: The research was performed on 120 young subjects (mean age 33 years), with various types of cardiac arrhythmias, on normal heart, without co-existing lesions. Subjects were divided into 3 groups (40 persons). The first 2 groups included subjects with cardiac arrhythmias. Group I also associated dyslipidemia; group II, without dyslipidemia and group III: control. Determination of TAS values was performed using ABTS (2-azino-di-3-ethylbenzthiazoline sulfonate) colorimetic method. Results were statistically processed. Results: TAS values were decreased in all patients with cardiac arrhythmias, representing 52-54% of the values of healthy controls, the data being highly statistically significant. The variation of TAS decrease by types of arrhythmias was thus found in patients with arrhythmias and associated dyslipidemia and, respectively, without dyslipidemia, compared to controls. The deficit of antioxidant activity, between 48%-46% triggers electrochemical processes with implications in arrhythmogenesis and lipid oxidation. Coffee and vegetables-rich diet have antioxidant effect, reducing TAS deficiency. Conclusions: 1. TAS was decreased in all subjects with non-lesional arrhythmias. The study showed decreasing TAS level at 52-54% in patients with arrhythmias, with/without dyslipidemia, compared to controls. 2. TAS deficiency was associated with various types of dysrhythmias, ranging from 62% to 33%. 3. Decreased TAS also triggers lipid oxidation, as risk factor for early atherosclerotic lesions.
青年非损伤性心律失常患者总抗氧化活性的变化
总抗氧化活性状态(TAS)代表身体对氧化应激的反应,在氧化的致病性评估中很重要。目的:确定患有非病变性心律失常、伴有/不伴有血脂异常的年轻受试者的TAS变化,并评估脂质氧化的风险。患者和方法:研究对象为120名年轻受试者(平均年龄33岁),他们患有各种类型的心律失常,心脏正常,无共存病变。受试者被分为3组(40人)。前2组包括心律失常的受试者。I组还伴有血脂异常;第二组:无血脂异常,第三组:对照组。TAS值的测定使用ABTS(2-锌基二-3-乙基苯并噻唑啉磺酸盐)比色法进行。对结果进行统计处理。结果:所有心律失常患者的TAS值均下降,占健康对照组的52-54%,数据具有高度统计学意义。因此,与对照组相比,在有心律失常和相关血脂异常的患者和没有血脂异常的病人中,发现TAS降低随心律失常类型的变化。抗氧化活性的缺乏,在48%-46%之间触发电化学过程,与心律失常和脂质氧化有关。富含咖啡和蔬菜的饮食具有抗氧化作用,减少TAS缺乏。结论:1。所有非病变性心律失常受试者的TAS均降低。研究表明,与对照组相比,心律失常伴/不伴血脂异常的患者的TAS水平降低了52-54%。2.TAS缺乏与各种类型的心律失常有关,从62%到33%不等。3.TAS降低也会触发脂质氧化,这是早期动脉粥样硬化病变的危险因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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