Cerebrospinal Fluid Flow

IF 25.4 1区 工程技术 Q1 MECHANICS
D. H. Kelley, John H. Thomas
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引用次数: 11

Abstract

Circulation of cerebrospinal fluid and interstitial fluid around the central nervous system and through the brain transports not only those water-like fluids but also any solutes they carry, including nutrients, drugs, and metabolic wastes. Passing through brain tissue primarily during sleep, this circulation has implications for neurodegenerative disorders including Alzheimer's disease, for tissue damage during stroke and cardiac arrest, and for flow-related disorders such as hydrocephalus and syringomyelia. Recent experimental results reveal several features of this flow, but other aspects are not fully understood, including its driving mechanisms. We review the experimental evidence and theoretical modeling of cerebrospinal fluid flow, including the roles of advection and diffusion in transporting solutes. We discuss both local, detailed fluid-dynamic models of specific components of the system and global hydraulic models of the overall network of flow paths. Expected final online publication date for the Annual Review of Fluid Mechanics, Volume 55 is January 2023. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
脑脊液流动
脑脊液和间质液在中枢神经系统周围和通过大脑的循环不仅输送这些类水的液体,还输送它们携带的任何溶质,包括营养物质、药物和代谢废物。这种循环主要在睡眠期间通过脑组织,对包括阿尔茨海默病在内的神经退行性疾病、中风和心脏骤停期间的组织损伤以及脑积水和脊髓空洞症等与流量相关的疾病都有影响。最近的实验结果揭示了这种流动的几个特征,但其他方面还没有完全了解,包括它的驱动机制。我们综述了脑脊液流动的实验证据和理论模型,包括平流和扩散在溶质传输中的作用。我们讨论了系统特定组件的局部详细流体动力学模型和整个流道网络的全局水力模型。《流体力学年度评论》第55卷预计最终在线出版日期为2023年1月。请参阅http://www.annualreviews.org/page/journal/pubdates用于修订估算。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
54.00
自引率
0.40%
发文量
43
期刊介绍: The Annual Review of Fluid Mechanics is a longstanding publication dating back to 1969 that explores noteworthy advancements in the field of fluid mechanics. Its comprehensive coverage includes various topics such as the historical and foundational aspects of fluid mechanics, non-newtonian fluids and rheology, both incompressible and compressible fluids, plasma flow, flow stability, multi-phase flows, heat and species transport, fluid flow control, combustion, turbulence, shock waves, and explosions. Recently, an important development has occurred for this journal. It has transitioned from a gated access model to an open access platform through Annual Reviews' innovative Subscribe to Open program. Consequently, all articles published in the current volume are now freely accessible to the public under a Creative Commons Attribution (CC BY) license. This new approach not only ensures broader dissemination of research in fluid mechanics but also fosters a more inclusive and collaborative scientific community.
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