Protective Effects of Vitamin D3 on Male Rat’s Hepatic Cell Injured by Diclofenac, A Histopathological Study

mjl@ lnbr ll`lwm lbyTry@ Pub Date : 2022-12-15 DOI:10.37940/ajvs.2022.15.2.10

Ali A. Tala’a

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Abstract

This experiment aimed to study the protective effects of vitamin D3 on hepatic cells injured by Diclofenac. Twenty-one male rats, 8 to 12 weeks of age and in weight from 180 to 220 grams, were housed in a standard, pathogen-free environment in the “College of Veterinary Medicine, University of Fallujah,” given unrestricted access to standard rat water and food. Then the rats were divided into 3 groups (each group containing 7 rats): G1 control group (IM injection of distill water for 7 days), G2 Diclofenac only (7-day course of a 10 mg/kg IM injection of diclofenac), G3 received intramuscular injections of VD3 three times per week at a dose of 1000 IU/Kg, then a 7-day course of a 10 mg/kg IM injection of diclofenac. Liver histological sections of the normal control (G1) showed no histopathological changes, while the histopathological sections of the liver of G2 exhibit hydropic degeneration, blood vessels congestion and inflammatory cell infiltration, Liver sections of G3 presented blood vessels congestion and mild inflammatory cell infiltration. This study concluded that VD3 can decrease the liver damage caused by diclofenac

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维生素D3对双氯芬酸损伤公鼠肝细胞保护作用的组织病理学研究

本实验旨在研究维生素D3对双氯芬酸损伤肝细胞的保护作用。21只雄性大鼠，8至12周龄，体重180至220克，被安置在费卢杰大学兽医学院的标准无病原体环境中，可以不受限制地获得标准的老鼠水和食物。然后将大鼠分为3组（每组7只大鼠）：G1对照组（蒸馏水IM注射7天），G2只注射双氯芬酸（10 mg/kg IM注射双氯芬酸7天疗程），G3每周肌肉注射3次VD3，剂量为1000 IU/kg，然后注射10 mg/kg IM双氯芬酸7天疗程。正常对照组（G1）的肝脏组织学切片没有组织病理学变化，而G2的肝脏组织病理学切片表现为水肿变性、血管充血和炎症细胞浸润，G3的肝脏切片表现为血管充血和轻度炎症细胞浸润。本研究得出结论，VD3可以减少双氯芬酸引起的肝损伤

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18 weeks