Probiotics for Prosperity: Is There a Role for Probiotics in the Fight Against Obesity? Review of Meta-Analyses of Randomized Controlled Trials

IF 1.3 Q4 NUTRITION & DIETETICS

Nutrition and Dietary Supplements Pub Date : 2020-11-01 DOI:10.2147/nds.s243097

E. Barengolts, Michael Salim, Arfana Akbar, F. Salim

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引用次数: 1

Abstract

Purpose: Obesity is a chronic disease that is acquiring pandemic proportions. Emerging research suggests that probiotics can be a valuable yet still an underutilized modality for obesity treatment. This review aims to analyze and summarize recent data focusing on published meta-analyses of randomized controlled trials (RCTs) to help understand the role of probiotics in fighting obesity. Materials and Methods: Meta-analyses were sought and reviewed from PubMed, Cochrane Central Library, ScienceDirect, and Google Scholar for body weight and/or BMI changes (two main outcomes of interest). Results: The literature review identified 14 meta-analyses. On average, the meta-analyses dedicated to probiotics included 4–15 trials with 154–994 participants, whereas more inclusive probiotics and/or synbiotics analyses included 15–68 trials with 895–4015 participants. Eleven out of 14 meta-analyses showed that probiotic use in RCTs resulted in reduced body weight and/or BMI compared to placebo. An average weight loss was 0.6 kg, and the most substantial loss was 4.8 kg corresponding to 0.7% and 5.9% reductions in body weight, respectively. Probiotics’ use was associated with improved health outcomes in addition to weight loss and was safe. The subgroup analyses showed that the probiotic forms (supple-ments vs food) and the dosages (lower vs higher than 10 10 CFU/day) did not substantially influence weight loss. The single species particularly helpful for weight loss appeared to be casei, L. delbrueckii, L. reuteri, L. rhamnosus , a combination of L. curvatus and L. plantarum and Bifidobacterium longum. Bacillus subtilis and Akkermansia muciniphila also had a potential as anti-obesity probiotics. Conclusion: Probiotics, despite small effects, could be a valuable addition to the armamentarium of obesity management. Further basic and translational research and clinical trials are required to elucidate mechanisms and specific probiotic and patients’ types for the best achievable precision medicine approach to the obesity epidemic. A combination of the following

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益生菌促进繁荣:益生菌在对抗肥胖中有作用吗?随机对照试验荟萃分析综述

目的:肥胖是一种慢性疾病，其流行程度越来越高。新兴研究表明，益生菌可能是一种有价值但仍未充分利用的肥胖治疗方式。本综述旨在分析和总结近期发表的随机对照试验(rct)荟萃分析数据，以帮助了解益生菌在对抗肥胖中的作用。材料和方法:从PubMed、Cochrane中央图书馆、ScienceDirect和谷歌Scholar中寻找并回顾了体重和/或BMI变化的meta分析(两个主要的研究结果)。结果:文献综述确定了14项荟萃分析。平均而言，专注于益生菌的荟萃分析包括4-15项试验，154-994名参与者，而更广泛的益生菌和/或合成分析包括15-68项试验，895-4015名参与者。14项荟萃分析中有11项显示，与安慰剂相比，随机对照试验中使用益生菌导致体重和/或BMI降低。平均体重减轻0.6公斤，最显著的体重减轻4.8公斤，分别相当于体重减轻0.7%和5.9%。除了体重减轻外，益生菌的使用还与改善健康状况有关，而且是安全的。亚组分析表明，益生菌的形式(补充剂与食物)和剂量(低于10 / 10 CFU/天vs高于10 / 10 CFU/天)对体重减轻没有实质性影响。对减肥特别有帮助的单一物种似乎是干酪乳杆菌、德尔布鲁氏乳杆菌、罗伊氏乳杆菌、鼠李糖乳杆菌、弯曲乳杆菌、植物乳杆菌和长双歧杆菌的组合。枯草芽孢杆菌和嗜粘阿克曼氏菌也有作为抗肥胖益生菌的潜力。结论:益生菌虽然效果不大，但可能是肥胖管理的一个有价值的补充。需要进一步的基础研究、转化研究和临床试验来阐明机制、特定的益生菌和患者类型，以实现针对肥胖流行的最佳精准医学方法。以下内容的组合

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来源期刊

Nutrition and Dietary Supplements NUTRITION & DIETETICS-

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审稿时长

16 weeks

期刊介绍： Nutrition and Dietary Supplements is an international, peer-reviewed, open access journal focusing on research into nutritional requirements in health and disease, impact on metabolism and the identification and optimal use of dietary strategies and supplements necessary for normal growth and development. Specific topics covered in the journal include: Epidemiology, prevalence of related disorders such as obesity, diabetes, dyslipidemias Biochemistry and cellular metabolism of nutrients Effect of nutrition on metabolic control Impact of hormones and genetics on nutrient handling Identification of cofactors and development of effective supplementation strategies Dietary strategies Behavior modification Consumer and patient adherence, quality of life Public Health Policy & Health Economics.