Theoretical assessment of the impact of awareness programs on cholera transmission dynamic

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Daudel Tchatat, G. Kolaye, S. Bowong, A. Temgoua
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引用次数: 2

Abstract

Abstract In this paper, we propose and analyse a mathematical model of the transmission dynamics of cholera incorporating awareness programs to study the impact of socio-media and education on cholera outbreaks. These programs induce behavioural changes in the population, which divide the susceptible class into two subclasses, aware individuals and unaware individuals. We first provide a basic study of the model. We compute the Disease-Free Equilibrium (DFE) and derive the basic reproduction number R 0 0 ${\mathcal{R}}_{0}^{0}$ that determines the extinction and the persistence of the disease. We show that there exists a threshold parameter ξ such that when R 0 0 ≤ ξ < 1 ${\mathcal{R}}_{0}^{0}\le \xi < 1$ , the DFE is globally asymptotically stable, but when ξ ≤ R 0 0 < 1 $\xi \le {\mathcal{R}}_{0}^{0}< 1$ , the model exhibits the phenomenon of backward bifurcation on a feasible region. The model exhibits one endemic equilibrium locally stable when R 0 0 > 1 ${\mathcal{R}}_{0}^{0} > 1$ and in that condition the DFE is unstable. Various cases for awareness proportions are performed using the critical awareness rate in order to measure the effect of awareness programs on the infected individuals over time. The results we obtained show that the higher implementation of strategies combining awareness programs and therapeutic treatments increase the efficacy of control measures. The numerical simulations of the model are used to illustrate analytical results and give more precision on critical values on the controls actions.
提高认识方案对霍乱传播动态影响的理论评估
在本文中,我们提出并分析了霍乱传播动力学的数学模型,其中包括意识计划,以研究社会媒体和教育对霍乱爆发的影响。这些程序会引起人群的行为改变,从而将易感人群分为两个子类,有意识的个体和无意识的个体。我们首先对该模型进行了基础研究。我们计算了无病平衡(disease - free Equilibrium, DFE),并推导出决定疾病灭绝和持续的基本繁殖数R 0 0 ${\mathcal{R}}_{0}^{0}$。我们证明了存在一个阈值参数ξ,使得当R 0 0≤ξ < 1 ${\mathcal{R}}_{0}^{0}\le \xi < 1$时,DFE是全局渐近稳定的,但当ξ≤R 0 0 < 1 $\xi \le {\mathcal{R}}_{0}^{0}< 1$时,模型在可行区域上呈现后向分岔现象。当r0 0 > 1 ${\mathcal{R}}_{0}^{0} > 1$时,模型表现出一个局部稳定的地方性平衡,此时DFE是不稳定的。使用临界知晓率来执行各种情况下的知晓率比例,以衡量随着时间的推移,知晓率方案对受感染个体的影响。结果表明,意识规划与治疗相结合的策略的实施程度越高,控制措施的效果越好。该模型的数值模拟用于说明分析结果,并给出了更精确的控制动作临界值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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