Review on Determination of Berberine in Biological and Pharmaceutical Matrices: An Analytical and Therapeutic Perspective

IF 0.7 4区医学 Q4 PHARMACOLOGY & PHARMACY

Current Pharmaceutical Analysis Pub Date : 2023-05-05 DOI:10.2174/1573412919666230505095457

Umang Shah, Meghana Patel, Alkesh Patel, K. Patel, Mehul Patel, A. Akabari, Samir G Patel, Veena S Patel, R. Maheshwari, A. Sen, N. Sethiya

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引用次数: 1

Abstract

Berberine (BRB) is a natural alkaloid of the isoquinoline class, mostly isolated from the Berberis genus, which exhibits antibiotic, immunostimulant, antitumor, cardiovascular protection, endocrine regulator, antidepressant, neuroprotective, antioxidant, anti-inflammatory, and other pharmacological properties. The poor aqueous solubility of BRB is one roadblock in scaling up activities for the clinical drug. However, this can be overcome by its chemical modification into salt form. Extraction of this biologically beneficial component becomes one of the important aspects, and for that, several extraction techniques are available using a variety of solvents. Numerous analytical methods are reported for the quantification of extracted BRB as well as simultaneous estimation of BRB in the presence of other components. Among them, RP-HPLC, LC/MS, and UPLC/MS are the most frequently used methods. The effectiveness and preciseness of these advanced methods could be the reason for analysts’ preferred choice for analysis.

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生物和药物基质中黄连素含量测定的分析和治疗研究进展

小檗碱（BRB）是一种异喹啉类天然生物碱，主要从小檗属植物中分离得到，具有抗菌、免疫刺激、抗肿瘤、心血管保护、内分泌调节、抗抑郁、神经保护、抗氧化、抗炎等药理特性。BRB的水溶性差是临床药物扩大活性的一个障碍。然而，这可以通过将其化学改性为盐的形式来克服。提取这种生物有益成分成为重要方面之一，为此，可以使用多种溶剂使用几种提取技术。据报道，许多分析方法用于定量提取的BRB以及在存在其他成分的情况下同时估计BRB。其中，RP-HPLC、LC/MS和UPLC/MS是最常用的方法。这些先进方法的有效性和准确性可能是分析师首选分析的原因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Pharmaceutical Analysis 医学-药学

CiteScore

1.50

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： Aims & Scope Current Pharmaceutical Analysis publishes expert reviews and original research articles on all the most recent advances in pharmaceutical and biomedical analysis. All aspects of the field are represented including drug analysis, analytical methodology and instrumentation. The journal is essential to all involved in pharmaceutical, biochemical and clinical analysis.