Changes of resting state fMRI brain imaging in patients with depression after antidepressant treatment

中华行为医学与脑科学杂志 Pub Date : 2020-02-20 DOI:10.3760/CMA.J.CN371468-20190523-00335

Jian Cui, Yun Wang, Yuan Zhou, Gang Wang

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引用次数: 0

Abstract

Antidepressant therapy is effective for patients with major depressive disorder, however the mechanism is unclear and it is difficult to predict the efficacy objectively. At present, the changes of local spontaneous brain activity in patients with major depressive disorder after antidepressant treatment are mostly located in the dorsolateral prefrontal cortex, ventromedial prefrontal cortex, anterior cingulate gyrus and precuneus. The changes of brain function interaction involved in emotional circuit, default mode network, central executive network and hypothalamus-pituitary-adrenal axis.Future researches should optimize the experimental design, enlarge the sample size, reduce the sample heterogeneity, and compare the effects of different types of antidepressants. This paper reviews the effects of antidepressant therapy on brain function in patients with major depressive disorder from the perspective of resting fMRI, to promote our understanding of the mechanism of antidepressant therapy and to promote the discovery of objective biomarkers which can predict the response of antidepressant therapy. Key words: Major depressive disorder; Antidepressants; Resting state; Functional magnetic resonance imaging

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抑郁症患者抗抑郁治疗后静息状态fMRI脑成像的变化

抗抑郁治疗对重度抑郁症患者是有效的，但其作用机制尚不清楚，也难以客观预测其疗效。目前，重度抑郁症患者在抗抑郁治疗后局部自发脑活动的变化主要位于背外侧前额叶皮层、腹内侧前额叶皮质、前扣带回和楔前叶。脑功能相互作用的变化涉及情绪回路、默认模式网络、中枢执行网络和下丘脑-垂体-肾上腺轴。未来的研究应该优化实验设计，扩大样本量，减少样本异质性，并比较不同类型抗抑郁药的效果。本文从静息功能磁共振成像的角度综述了抗抑郁治疗对重度抑郁障碍患者大脑功能的影响，以促进我们对抗抑郁治疗机制的理解，并促进发现可以预测抗抑郁治疗反应的客观生物标志物。关键词：重度抑郁障碍；抗抑郁药；休息状态；功能性磁共振成像

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来源期刊

中华行为医学与脑科学杂志

自引率

0.00%

发文量

8131

期刊介绍： "Chinese Journal of Behavioral Medicine and Brain Science" (CN 37-1468/R, ISSN 1674-6554) is a national academic journal under the supervision of the National Health Commission, sponsored by the Chinese Medical Association and Jining Medical College. The journal was founded in June 1992 and was formerly known as "Chinese Journal of Behavioral Medicine" (1992-1993) and "Chinese Behavioral Medical Science" (1994-2008). In 2009, it was renamed "Chinese Journal of Behavioral Medicine and Brain Science" with the approval of the State Administration of Press, Publication, Radio, Film and Television. The purpose of "Chinese Journal of Behavioral Medicine and Brain Science" is to implement the health and health policies of the Party and the State, implement the principle of combining theory with practice and popularization and improvement, and reflect the major progress in the theory and practical application of behavioral medicine and brain science in my country. It publishes academic papers and scientific research results in the field of behavioral medicine and brain science in my country, and has columns such as monographs/reviews, basic research, clinical research, health prevention, methods and techniques, psychological behavior and evaluation, and systematic evaluation.