Syzygium aromaticum extracts debilitate Candida albicans by radically inhibiting its morphological plasticity and biofilm formation

IF 1.2 Q4 PHARMACOLOGY & PHARMACY

Journal of Herbs, Spices and Medicinal Plants Pub Date : 2023-04-02 DOI:10.1080/10496475.2023.2196463

Omar K.H. Bani Domi, H. Darmani

引用次数: 0

Abstract

ABSTRACT The effects of Syzygium aromaticum extracts on the growth, germ tube production, biofilm formation and adhesion of Candida albicans to human buccal epithelial cells (BEC) were investigated. We found larger zones of inhibition of growth of C. albicans with the essential oil (EO) and methanolic extract (ME) than amphotericin B. Similarly, the MIC values for the EO and ME were lower than that of amphotericin B. The EO and ME caused greater reductions in biofilm formation than amphotericin-B. Pre-treatment of C. albicans and BEC with the EO caused greater reductions in adhesion to BEC than amphotericin B.

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丁香提取物通过从根本上抑制白色念珠菌的形态可塑性和生物膜的形成而使其衰弱

摘要本文研究了香薷提取物对白色念珠菌生长、芽管生成、生物膜形成及与人颊上皮细胞(BEC)粘附的影响。我们发现精油(EO)和甲醇提取物(ME)对白色念珠菌生长的抑制区域比两性霉素b更大。同样，EO和ME的MIC值低于两性霉素b。EO和ME比两性霉素b更能减少生物膜的形成。与两性霉素B相比，用EO预处理白色念珠菌和BEC对BEC的粘附减少更大。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Herbs, Spices and Medicinal Plants Medicine-Complementary and Alternative Medicine

CiteScore

3.00

自引率

0.00%

发文量

期刊介绍： The Journal of Herbs, Spices & Medicinal Plants is an essential reference filled with recent research and other valuable information associated with herbs, spices, and medicinal plants. The Journal serves as a focus point through which investigators and others may publish material of importance to the production, marketing, and utilization of these plants and associated extracts. The journal covers the following topics: growth, development, horticulture, ecology, physiology, genetics, chemistry, and economics. Original articles, review articles, and book reviews provide information of interest to an international audience of researchers, teachers, technicians, and managers involved with production and/or marketing of herbs, spices, and medicinal plants. Managers of food companies, food processing facilities, medical research laboratories, government agencies, and others interested in new chemicals, food additives, international trade, patents, and other items can easily review new findings. The Journal of Herbs, Spices & Medicinal Plants is a forum in which recent research and other information associated with herbs, spices, and medicinal plants is shared. The Journal represents a centralized database accessible by investigators within the international community that work with or have an interest in herbs, spices, and medicinal plants.