Antimicrobial potency of toothpaste containing gambir (Uncaria gambir) extract

Padjadjaran Journal of Dentistry Pub Date : 2023-08-13 DOI:10.24198/pjd.vol35no2.47130

Siti Rusdiana Puspa Dewi, Pudji Handayani, Danica Anastasia, Shania Tri Maulina

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Abstract

ABSTRACTIntroduction: The biggest problem in oral health is dental caries and periodontal disease. The way to prevent dental and mouth problems is to keep oral hygiene. One of them is adequate plaque control. Plaque control can be done by brushing teeth and using toothpaste. Currently, many herbal ingredients have been used as antibacterials such as gambir (Uncaria gambir). Gambir mainly contains catechins and tannins, which have the ability to inhibit the growth of bacteria. The purpose of this study was to determine the antimicrobial potential of toothpaste containing gambir (Uncaria gambir). Methods: The total sample was 30, and it divided into three groups. Samples were toothpaste containing ten percent of Uncaria gambir extract, fluoride, placebo toothpaste, Streptococcus mutans (Gram-positive), Phorphyromonas gingivalis (Gram-negative), and Candida albicans. Antimicrobial activity of toothpaste with gambir (Uncaria gambir) extract against microorganisms was observed with the formation of inhibitory zone diameter in agar. Data were analyzed by using SPSS with one-way ANOVA and Tukey test. Results: The results showed that toothpaste containing gambir extract could inhibit the Streptococcus mutans (p<0.05), Phorphyromonas gingivalis (p<0.05), Candida albicans (p<0.05) compared significantly with placebo (p<0.05). Antimicrobial toothpaste containing gambir extract had no different effect from toothpaste containing fluoride. However, toothpaste containing gambir extract had significantly different effect than toothpaste containing fluoride. Conclusion: It can be concluded that toothpaste containing gambir (Uncaria gambir) extract has antimicrobial potential against Streptococcus mutans, Phorphyromonas gingivalis, and Candida albicans. These findings showed that the extract of Uncaria gambir possesses potent antimicrobial activity. KEYWORDantimicrobial, Candida albicans, Phorphyromonas gingivalis, Streptococcus mutans, Uncaria gambir

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冈比亚钩藤提取物牙膏的抗菌效力

摘要简介：口腔健康的最大问题是龋齿和牙周病。预防牙齿和口腔问题的方法是保持口腔卫生。其中之一是充分控制斑块。牙菌斑的控制可以通过刷牙和使用牙膏来完成。目前，许多草药成分已被用作抗菌药物，如甘比尔（钩藤）。甘比尔主要含有儿茶素和单宁，它们具有抑制细菌生长的能力。本研究的目的是确定含有甘布的牙膏（钩藤）的抗菌潜力。方法：共30例，分为三组。样本为含有10%钩藤提取物的牙膏、氟化物、安慰剂牙膏、变形链球菌（革兰氏阳性）、牙龈卟啉单胞菌（革兰氏阴性）和白色念珠菌。在琼脂中形成抑菌带直径，观察甘布提取物牙膏对微生物的抗菌活性。数据分析采用SPSS软件，单因素方差分析和Tukey检验。结果：含甘比尔提取物的牙膏对变形链球菌（p<0.05）、牙龈卟啉单胞菌（p<0.05）和白色念珠菌（p<0.05）的抑制作用与安慰剂组比较有显著性差异（p<0.05）。然而，含有甘比尔提取物的牙膏与含有氟化物的牙膏具有显著不同的效果。结论：含有甘比尔提取物的牙膏对变形链球菌、牙龈卟啉单胞菌和白色念珠菌具有抗菌潜力。研究结果表明，钩藤提取物具有较强的抗菌活性。关键词念珠菌、白色念珠菌、牙龈卟啉单胞菌、变形链球菌、钩藤

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来源期刊

Padjadjaran Journal of Dentistry

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审稿时长

3 weeks