Arsenic and Human Health: New Molecular Mechanisms For Arsenic-Induced Cancers

IF 6.4 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Current Pollution Reports Pub Date : 2023-08-23 DOI:10.1007/s40726-023-00278-3

Alexandra N. Nail, Manting Xu, Jonathan C. Bastick, Deep P. Patel, Max N. Rogers, J. Christopher States

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Abstract

Purpose of Review

Chronic inorganic arsenic (iAs) exposure affects over 220 million people throughout the world. Given that iAs is ubiquitous in the environment, it is important to understand the human health consequences of chronic iAs exposure. The purpose of this review is to highlight and evaluate research findings within the past 5 years that address the molecular mechanisms responsible for cancers caused by chronic iAs exposure. We also propose new research directions for the iAs research field based on the newest uncovered mechanisms for how this age-old poison promotes cancer.

Recent Findings

Within the past 5 years, studies provide evidence that chronic iAs exposure promotes kidney, prostate, liver, and breast cancer in humans. New molecular mechanisms that promote cancer development by iAs exposure in skin, lung, bladder, kidney, prostate, liver, and breast include histone modifications, DNA and RNA methylation, non-coding RNA expression, disruption of alternative splicing, and inhibition of the DNA damage response.

Summary

Recent studies highlight disruption of epigenetic and epitranscriptomic modifications and/or the DNA damage response by chronic iAs exposure across many models of iAs-induced carcinogenesis, including cancers that are not classically defined as being caused by chronic iAs exposure. Understanding the molecular mechanisms underlying initiation and metastasis of iAs-induced cancers is essential for improving detection and targeted treatment of iAs-induced cancers.

Graphical Abstract

Abstract Image

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砷与人类健康:砷诱发癌症的新分子机制

综述目的长期接触无机砷（iAs）影响着全世界超过 2.2 亿人。鉴于 iAs 在环境中无处不在，了解长期暴露于 iAs 对人类健康的影响非常重要。本综述旨在重点介绍和评估过去 5 年中有关慢性砷暴露导致癌症的分子机制的研究成果。我们还根据最新发现的碘砷这种古老毒物如何诱发癌症的机制，为碘砷研究领域提出了新的研究方向。最新发现在过去 5 年中，有研究提供证据表明，长期暴露于碘砷会诱发人类肾癌、前列腺癌、肝癌和乳腺癌。新的分子机制包括组蛋白修饰、DNA 和 RNA 甲基化、非编码 RNA 表达、替代剪接的破坏以及 DNA 损伤反应的抑制。摘要最近的研究突出表明，在许多碘砷诱导的致癌模型中，长期暴露于碘砷会破坏表观遗传学和表观转录组的修饰和/或 DNA 损伤反应，包括未被经典定义为由长期暴露于碘砷引起的癌症。了解碘砷诱导的癌症发生和转移的分子机制对于改进碘砷诱导的癌症的检测和靶向治疗至关重要。

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来源期刊

Current Pollution Reports Environmental Science-Water Science and Technology

CiteScore

12.10

自引率

1.40%

发文量

期刊介绍： Current Pollution Reports provides in-depth review articles contributed by international experts on the most significant developments in the field of environmental pollution.By presenting clear, insightful, balanced reviews that emphasize recently published papers of major importance, the journal elucidates current and emerging approaches to identification, characterization, treatment, management of pollutants and much more.