The Association of Serum Anti-Lysosomal-Associated Membrane Protein-2 Antibody with Vasculitis Combined with Hypertension

IF 1.9 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

International Journal of Hypertension Pub Date : 2022-03-18 DOI:10.1155/2022/9656560

Bin Zhu, Xintian Cai, Qing Zhu, Ting Wu, Shasha Liu, Shanshan Liu, Jing Hong, Nan-fang Li

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引用次数: 1

Abstract

The aim of this study was to explore the association of serum anti-lysosomal-associated membrane protein-2 (anti-LAMP-2) antibody with vasculitis combined with hypertension (VAS-HTN). A total of 51 VAS-HTN patients, 46 essential hypertension (EH) patients, and 46 healthy controls (HC) were included in the study. Serum anti-LAMP-2 antibody levels are increased in VAS-HTN patients as compared with EH and HC (all P < 0.05). Serum anti-LAMP-2 antibody levels were significantly higher in active stage patients than those in non-active stage patients and HC (all P < 0.05). The correlation analysis showed a significant positive correlation between serum anti-LAMP-2 antibody levels and the Birmingham Vasculitis Activity Score (BVAS) and hypersensitive C-reactive protein (Hs-CRP) (all P < 0.05). Among the subsets of VAS-HTN, the levels of serum anti-LAMP-2 antibody were remarkably higher in all VAS-HTN subsets compared with HC (all P < 0.05). More interestingly, the levels of serum anti-LAMP-2 antibody were remarkably increased in polyarteritis nodosa (PAN) patients compared with ANCA-associated vasculitis and Takayasu arteritis patients (all P < 0.05). In addition, there was a significant positive correlation between serum anti-LAMP-2 antibody levels and BAVS and Hs-CRP in PAN patients (all P < 0.05). Multivariate logistic regression analysis showed that the anti-LAMP-2 antibody was independently associated with VAS-HTN. The levels of serum anti-LAMP-2 antibody were remarkably increased in VAS-HTN patients compared to EH and HC and might reflect the disease activity. The anti-LAMP-2 antibody may be a potential biomarker for diagnosis and estimating the disease activity in VAS-HTN.

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血清抗溶酶体相关膜蛋白-2抗体与血管炎合并高血压的关系

本研究旨在探讨血清抗溶酶体相关膜蛋白-2 (anti-LAMP-2)抗体与血管炎合并高血压(VAS-HTN)的关系。本研究共纳入51例VAS-HTN患者、46例原发性高血压(EH)患者和46例健康对照(HC)。VAS-HTN患者血清抗lamp -2抗体水平高于EH和HC(均P < 0.05)。活动期患者血清抗lamp -2抗体水平明显高于非活动期和HC患者(均P < 0.05)。相关性分析显示，血清抗lamp -2抗体水平与伯明翰血管炎活动性评分(BVAS)、超敏c反应蛋白(Hs-CRP)呈显著正相关(P < 0.05)。在VAS-HTN各亚群中，血清抗lamp -2抗体水平均显著高于HC (P < 0.05)。更有趣的是，与anca相关血管炎和高松动脉炎患者相比，结节性多动脉炎(PAN)患者血清抗lamp -2抗体水平显著升高(均P < 0.05)。此外，PAN患者血清抗lamp -2抗体水平与BAVS、Hs-CRP呈显著正相关(P < 0.05)。多因素logistic回归分析显示抗lamp -2抗体与VAS-HTN独立相关。与EH和HC相比，VAS-HTN患者血清抗lamp -2抗体水平显著升高，可能反映了疾病的活动性。抗lamp -2抗体可能是VAS-HTN诊断和评估疾病活动性的潜在生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Hypertension Medicine-Internal Medicine

CiteScore

4.00

自引率

5.30%

发文量

期刊介绍： International Journal of Hypertension is a peer-reviewed, Open Access journal that provides a forum for clinicians and basic scientists interested in blood pressure regulation and pathophysiology, as well as treatment and prevention of hypertension. The journal publishes original research articles, review articles, and clinical studies on the etiology and risk factors of hypertension, with a special focus on vascular biology, epidemiology, pediatric hypertension, and hypertensive nephropathy.