Gut microbiota interacts with intrinsic brain activity of patients with amnestic mild cognitive impairment

IF 11.1 1区医学 Q1 CLINICAL NEUROLOGY

Alzheimer's & Dementia Pub Date : 2020-12-07 DOI:10.1002/alz.042290

Guoping Peng

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引用次数: 0

Abstract

Background

To explore the potential relationships among gut microbiota (GM), local brain spontaneous activity and neuropsychological characteristics in amnestic mild cognitive impairment (aMCI) patients.

Method

Twenty aMCI and 22 healthy control (HC) subjects were recruited. The GM composition was determined by 16S ribosomal RNA gene sequencing. Resting-state functional magnetic resonance imaging scans were performed, and fractional amplitude of low-frequency fluctuations (fALFF) was calculated across different frequencies. Spearman or Pearson correlation analysis was used to analyze the relationship between spontaneous brain activity and cognitive function, GM composition.

Result

aMCI patients had altered GM state and local spontaneous brain activity as compared with HC subjects. Correlation analysis showed that aMCI and HC groups had different “GM–intrinsic brain activity interaction” patterns. In aMCI group, the relative abundance (RA) of Bacteroides from phylum to genus level was positively correlated with fALFF value in the right middle temporal gyrus in slow 4 and negatively with that of cerebellar vermis in typical band. The Clostridiaceae RA was positively correlated with the fALFF value of the right lingual gyrus in the typical band (0.01-0.08 Hz). The Clostridiaceae and Blautia RA was positively correlated with the fALFF value of the left cerebellum in slow 4 (0.027–0.073 Hz). At slow 5 (0.01–0.027 Hz), the Firmicutes RA was negatively correlated with the fALFF value in the right inferior frontal gyrus. Correlation analysis showed that Clostridium members (Lachnospiraceae and Blautia) were positively while Veillonellaceae was negatively linked with cognition test. While Bacteroides was positively correlated with attention and computation, and negatively correlated with the three-step command score.

Conclusion

aMCI patients have a specific GM-intrinsic brain activity-cognitive function interaction pattern.

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肠道菌群与健忘轻度认知障碍患者内在脑活动的相互作用

背景探讨遗忘性轻度认知障碍(aMCI)患者肠道微生物群(GM)、局部脑自发活动和神经心理特征之间的潜在关系。方法招募aMCI 20例，健康对照22例。采用16S核糖体RNA基因测序法测定GM组成。静息状态功能磁共振成像扫描，并计算不同频率的低频波动分数幅值(fALFF)。采用Spearman或Pearson相关分析分析自发性脑活动与认知功能、GM成分的关系。结果与HC相比，aMCI患者的GM状态和局部自发性脑活动发生了改变。相关分析表明，aMCI组和HC组具有不同的“gm -内在脑活动相互作用”模式。在aMCI组中，从门到属水平的拟杆菌相对丰度(RA)与慢4期右侧颞中回的fALFF值呈正相关，与典型带小脑蚓部的fALFF值呈负相关。梭菌科RA与右侧舌回典型波段(0.01 ~ 0.08 Hz)的fALFF值呈正相关。Clostridiaceae和Blautia RA与慢4 (0.027 ~ 0.073 Hz)左小脑fALFF值呈正相关。慢速5 (0.01 ~ 0.027 Hz)时，厚壁菌门RA与右侧额下回fALFF值呈负相关。相关分析表明，梭状芽孢杆菌科(Lachnospiraceae)和蓝藻属(Blautia)与认知测验呈正相关，而细绒杆菌科(Veillonellaceae)与认知测验呈负相关。拟杆菌类与注意力和计算能力呈正相关，与三步指令得分负相关。结论aMCI患者具有特定的gm -内在脑活动-认知功能相互作用模式。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.