Updates on the Interactions of Herbs Constituents with Cytochrome P450 Drug Metabolizing Enzymes

Q4 Pharmacology, Toxicology and Pharmaceutics

Current Enzyme Inhibition Pub Date : 2023-06-01 DOI:10.2174/1573408019666230601121657

Ahmed H Arbab, Elwaleed E. Zaroug, Tarig Omer Ahmed, Mahmoud M. E. Mudawi

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Abstract

Cytochrome P450 enzymes are the main drug-metabolizing enzyme, and their activity is influenced by numerous factors, including several plants’ constituents. Herbal products mediated induction or inhibition of cytochrome P450 leads to a change in drug metabolism and consequently, drug bioavailability, safety, therapeutic efficacy, and herb-drug interaction. Since herbal preparations are commonly used either alone or concomitantly with conventional drugs, understanding the interactions of plant constituents with cytochrome P450 is crucial. Therefore, this review highlighted plants with significant inhibition, induction, or modulatory /contradictory effects on human and animal cytochrome P450 enzymes. An extensive literature search was conducted on PubMed, ScienceDirect, and Google Scholar databases to identify relevant literature. About sixty medicinal plants with significant interaction with cytochrome P450 isoforms were summarized with their common uses and affected cytochrome P450 enzyme isoforms. Besides, representative examples of plant constituents and other factors contributing to plant-induced cytochrome P450 modulation and possible herb-drug interactions were also discussed in this review.

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中草药成分与细胞色素P450药物代谢酶相互作用研究进展

细胞色素P450酶是主要的药物代谢酶，其活性受到多种因素的影响，包括几种植物的成分。草药产品介导的细胞色素P450的诱导或抑制导致药物代谢的变化，从而导致药物生物利用度、安全性、治疗效果和草药-药物相互作用的变化。由于草药制剂通常单独使用或与传统药物同时使用，了解植物成分与细胞色素P450的相互作用至关重要。因此，这篇综述强调了植物对人类和动物细胞色素P450酶具有显著的抑制、诱导或调节/矛盾作用。在PubMed、ScienceDirect和Google Scholar数据库上进行了广泛的文献搜索，以确定相关文献。综述了约60种与细胞色素P450亚型有显著相互作用的药用植物及其常见用途和受影响的细胞色素P450酶亚型。此外，本文还讨论了植物成分和其他有助于植物诱导的细胞色素P450调节的因素的代表性例子，以及可能的中草药相互作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Enzyme Inhibition Pharmacology, Toxicology and Pharmaceutics-Drug Discovery

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： Current Enzyme Inhibition aims to publish all the latest and outstanding developments in enzyme inhibition studies with regards to the mechanisms of inhibitory processes of enzymes, recognition of active sites, and the discovery of agonists and antagonists, leading to the design and development of new drugs of significant therapeutic value. Each issue contains a series of timely, in-depth reviews written by leaders in the field, covering a range of enzymes that can be exploited for drug development. Current Enzyme Inhibition is an essential journal for every pharmaceutical and medicinal chemist who wishes to have up-to-date knowledge about each and every development in the study of enzyme inhibition.