{"title":"Recent developments in the greener approaches for the dithioacetalization of carbonyl compounds","authors":"Babli Roy","doi":"10.1080/17415993.2023.2239416","DOIUrl":null,"url":null,"abstract":"ABSTRACT The protection of carbonyl functional groups via dithioacetalization with thiols or dithiols plays a significant role in multi-step organic syntheses, such as natural products and drug synthesis. Therefore, dithioacetalization has always been cherished as one of the most important organic transformations in both academic and industrial research. Numerous synthetic strategies for the dithioacetalization of carbonyl compounds have been reported in the literature for the synthesis of industrially valuable organosulfur compounds or precursors like acyclic dithioacetals, dithiolanes, and dithianes. Regardless of having many conventional efficient synthetic protocols, greener approaches have been recognized as a viable alternative due to environmental and health concerns. Consequently, the growing trend of developing greener methods stimulated by the green chemistry concept for dithioacetalization is inevitable. The present review is aimed to highlight the recent advances in the greener and convenient synthetic approaches employed for the dithioacetalization of carbonyl compounds. GRAPHICAL ABSTRACT","PeriodicalId":17081,"journal":{"name":"Journal of Sulfur Chemistry","volume":null,"pages":null},"PeriodicalIF":2.1000,"publicationDate":"2023-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Sulfur Chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/17415993.2023.2239416","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
ABSTRACT The protection of carbonyl functional groups via dithioacetalization with thiols or dithiols plays a significant role in multi-step organic syntheses, such as natural products and drug synthesis. Therefore, dithioacetalization has always been cherished as one of the most important organic transformations in both academic and industrial research. Numerous synthetic strategies for the dithioacetalization of carbonyl compounds have been reported in the literature for the synthesis of industrially valuable organosulfur compounds or precursors like acyclic dithioacetals, dithiolanes, and dithianes. Regardless of having many conventional efficient synthetic protocols, greener approaches have been recognized as a viable alternative due to environmental and health concerns. Consequently, the growing trend of developing greener methods stimulated by the green chemistry concept for dithioacetalization is inevitable. The present review is aimed to highlight the recent advances in the greener and convenient synthetic approaches employed for the dithioacetalization of carbonyl compounds. GRAPHICAL ABSTRACT
期刊介绍:
The Journal of Sulfur Chemistry is an international journal for the dissemination of scientific results in the rapidly expanding realm of sulfur chemistry. The journal publishes high quality reviews, full papers and communications in the following areas: organic and inorganic chemistry, industrial chemistry, materials and polymer chemistry, biological chemistry and interdisciplinary studies directly related to sulfur science.
Papers outlining theoretical, physical, mechanistic or synthetic studies pertaining to sulfur chemistry are welcome. Hence the target audience is made up of academic and industrial chemists with peripheral or focused interests in sulfur chemistry. Manuscripts that truly define the aims of the journal include, but are not limited to, those that offer: a) innovative use of sulfur reagents; b) new synthetic approaches to sulfur-containing biomolecules, materials or organic and organometallic compounds; c) theoretical and physical studies that facilitate the understanding of sulfur structure, bonding or reactivity; d) catalytic, selective, synthetically useful or noteworthy transformations of sulfur containing molecules; e) industrial applications of sulfur chemistry; f) unique sulfur atom or molecule involvement in interfacial phenomena; g) descriptions of solid phase or combinatorial methods involving sulfur containing substrates. Submissions pertaining to related atoms such as selenium and tellurium are also welcome. Articles offering routine heterocycle formation through established reactions of sulfur containing substrates are outside the scope of the journal.