EXERCISE PREVENTS AGE-RELATED MEMORY DECLINE: THE ROLE OF NEUROTROPHIC FACTORS

Malang Neurology Journal Pub Date : 2020-06-25 DOI:10.21776/ub.mnj.2020.006.02.8

Arina Windri Rivarti, L. Herawati, H. Hidayati

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引用次数: 6

Abstract

Increasing aging population causes an increased prevalence of neurodegenerative diseases such as dementia that is associated with memory decline. Developing strategies for the prevention and therapy of age-related dementia is important to reduce the burden of treatment costs. Physical exercise is known to prevent cognitive decline and improve cognitive abilities. Physical exercise with moderate intensity for at least 150 minutes/week or 30 minutes/day for 5 days can reduce the incidence of degenerative diseases in the elderly. Thus, physical exercise appears as a simple, inexpensive, and affordable non-pharmacological therapy for most people. The processes of neurogenesis and neuronal survival involve the role of neurotrophic factors including BDNF, IGF-1 and VEGF, which are the three main neurotrophic factors that are known to increase after exercise. Many publications discuss about these neurotrophic factors, but their mechanism of signals and changes related to aging and exercise have not been completely studied. The purpose of this review is to discuss the mechanism of signals and changes of neurotrophic factors (focuses on BDNF, IGF-1, and VEGF) related to aging and exercise.

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运动预防与年龄相关的记忆力下降：神经营养因子的作用

人口老龄化导致神经退行性疾病的患病率增加，如与记忆力下降有关的痴呆症。制定与年龄相关的痴呆症的预防和治疗策略对于减轻治疗费用负担很重要。众所周知，体育锻炼可以防止认知能力下降，提高认知能力。中等强度的体育锻炼，每周至少150分钟或每天30分钟，持续5天，可以降低老年人退行性疾病的发生率。因此，对于大多数人来说，体育锻炼似乎是一种简单、廉价、负担得起的非药物疗法。神经发生和神经元存活的过程涉及神经营养因子的作用，包括BDNF、IGF-1和VEGF，这是已知运动后增加的三种主要神经营养因子。许多出版物都讨论了这些神经营养因子，但它们的信号机制以及与衰老和运动相关的变化尚未完全研究。这篇综述的目的是讨论神经营养因子（重点是BDNF、IGF-1和VEGF）与衰老和运动相关的信号和变化的机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Malang Neurology Journal

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审稿时长

48 weeks