Pseudomonas aeruginosa Biofilm Formation and Its Control

Aishwarya Vetrivel, Monica Ramasamy, P. Vetrivel, Santhi Natchimuthu, S. Arunachalam, G. Kim, Rajeswari Murugesan
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引用次数: 20

Abstract

Microbes are hardly seen as planktonic species and are most commonly found as biofilm communities in cases of chronic infections. Biofilms are regarded as a biological condition, where a large group of microorganisms gets adhered to a biotic or abiotic surface. In this context, Pseudomonas aeruginosa, a Gram-negative nosocomial pathogen is the main causative organism responsible for life-threatening and persistent infections in individuals affected with cystic fibrosis and other lung ailments. The bacteria can form a strong biofilm structure when it adheres to a surface suitable for the development of a biofilm matrix. These bacterial biofilms pose higher natural resistance to conventional antibiotic therapy due to their multiple tolerance mechanisms. This prevailing condition has led to an increasing rate of treatment failures associated with P. aeruginosa biofilm infections. A better understanding of the effect of a diverse group of antibiotics on established biofilms would be necessary to avoid inappropriate treatment strategies. Hence, the search for other alternative strategies as effective biofilm treatment options has become a growing area of research. The current review aims to give an overview of the mechanisms governing biofilm formation and the different strategies employed so far in the control of biofilm infections caused by P. aeruginosa. Moreover, this review can also help researchers to search for new antibiofilm agents to tackle the effect of biofilm infections that are currently imprudent to conventional antibiotics.
铜绿假单胞菌生物膜的形成及其控制
微生物几乎不被视为浮游物种,在慢性感染病例中最常被发现为生物膜群落。生物膜被认为是一种生物状态,一大群微生物附着在生物或非生物表面。在这种情况下,铜绿假单胞菌是一种革兰氏阴性的医院内病原体,是导致囊性纤维化和其他肺部疾病患者生命危险和持续感染的主要致病生物。当细菌附着在适合形成生物膜基质的表面时,可以形成牢固的生物膜结构。这些细菌生物膜由于具有多种耐受性机制,对常规抗生素治疗具有较高的天然耐药性。这种普遍的情况导致与铜绿假单胞菌生物膜感染相关的治疗失败率增加。为了避免不适当的治疗策略,有必要更好地了解不同种类的抗生素对已建立的生物膜的影响。因此,寻找其他替代策略作为有效的生物膜治疗方案已成为一个日益增长的研究领域。本综述旨在概述控制生物膜形成的机制以及迄今为止在铜绿假单胞菌引起的生物膜感染控制中采用的不同策略。此外,本综述还可以帮助研究人员寻找新的抗生物膜药物来解决生物膜感染对传统抗生素的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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