Prenatal Exposure to Alcohol Alters TLR4 Mediated Signaling in the Prefrontal Cortex in Rats

IF 0.6 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry Pub Date : 2022-05-17 DOI:10.1134/S1990750822020032

M. I. Airapetov, S. O. Eresko, E. R. Bychkov, A. A. Lebedev, P. D. Shabanov

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Abstract—

Prenatal alcohol exposure (PAE) can lead to developmental disorders of the central nervous system (CNS) and mental retardation. Toll-like receptor (TLR) 4 plays an important role in the development of defects in the nervous system caused by PAE. However, how PAE affects the TLR4 response in the brain remains unclear. Using the model of semi-forced alcoholization of pregnant rats, we have investigated TLR4-mediated signaling on the 30th day of postnatal development in their offspring. Rats exposed to PAE showed a higher expression of proinflammatory cytokines in the prefrontal cortex, but TLR4-mediated signaling in response to lipopolysaccharide (LPS) was weakened. These data suggest that PAE can lead to neuroinflammation and suppression of the TLR4-mediated response to LPS in the prefrontal cortex of young rats. Since innate immunity plays an important role in brain development, PAE-induced suppression of the TLR4-mediated response may be one of the mechanisms for the development of CNS pathology.

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产前酒精暴露改变大鼠前额皮质TLR4介导的信号传导

产前酒精暴露(PAE)可导致中枢神经系统(CNS)发育障碍和智力低下。toll样受体(TLR) 4在PAE引起的神经系统缺陷的发生发展中起重要作用。然而，PAE如何影响大脑中的TLR4反应仍不清楚。利用妊娠大鼠半强迫酒精化模型，我们研究了tlr4在其后代出生后发育第30天介导的信号通路。暴露于PAE的大鼠前额皮质中促炎细胞因子的表达较高，但tlr4介导的脂多糖(LPS)应答信号被削弱。这些数据表明，PAE可导致神经炎症和抑制tlr4介导的幼年大鼠前额皮质对LPS的反应。由于先天免疫在脑发育中起着重要作用，pae诱导的tlr4介导的应答抑制可能是中枢神经系统病理发展的机制之一。

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来源期刊

Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

1.10

自引率

0.00%

发文量

期刊介绍： Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry covers all major aspects of biomedical chemistry and related areas, including proteomics and molecular biology of (patho)physiological processes, biochemistry, neurochemistry, immunochemistry and clinical chemistry, bioinformatics, gene therapy, drug design and delivery, biochemical pharmacology, introduction and advertisement of new (biochemical) methods into experimental and clinical medicine. The journal also publishes review articles. All issues of the journal usually contain solicited reviews.