Indicadores de severidad clínica en la comorbilidad de trastorno bipolar y trastorno límite de personalidad: una revisión sistemática

Q3 Medicine

Revista Colombiana de Psiquiatria Pub Date : 2025-07-01 Epub Date: 2023-08-28 DOI:10.1016/j.rcp.2023.08.002

Glauco Valdivieso-Jiménez , Edgar Vásquez-Dextre , Sergio A. Barroilhet

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引用次数: 0

Abstract

Introduction

Bipolar disorder (BD) is a severe chronic mental health condition with significant morbidity and mortality. It is characterized by affective episodes of mania and depression, as well as mixed states. Borderline personality disorder (BPD) is characterized by emotional instability and a pattern of impulsive behavior associated with suicidality. Both diagnoses can be comorbid and present high dysfunction and severity.

Methods

The aim of this study was to describe the differential characteristics in terms of clinical severity, present in samples of patients with BD–BPD comorbidity versus samples of patients with only one of these diagnoses. A systematic review of the literature of cross-sectional, case–control and cohort studies was carried out in which samples of BD or BPD patients were compared with samples of BD–BPD comorbidity, published in English and Spanish, and that considered a population between 18 and 65 years old. Those studies that considered samples of patients with other comorbidities were excluded.

Results

A total of 12 studies were included, which included a total of 4246 patients of both sexes. The comorbidity of BD and BPD presented higher suicidality, depressive episodes and mania/hypomania, aggressiveness, anger and hostility, hospitalizations, worse functioning and greater severity of symptoms compared to those with a single diagnosis, especially BD.

Conclusions

The comorbidity of BD and BPD presents evidence of a greater impact on the clinical course compared to those who do not present this condition.

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双相情感障碍和边缘性人格障碍共病的临床严重程度指标:系统综述

双相情感障碍（BD）是一种严重的慢性精神疾病，发病率和死亡率都很高。它的特点是躁狂和抑郁的情感发作，以及混合状态。边缘型人格障碍（BPD）的特征是情绪不稳定和与自杀相关的冲动行为模式。这两种诊断都可能是合并症，表现出高度功能障碍和严重程度。方法本研究的目的是描述患有BD-BPD合并症的患者样本与仅患有其中一种诊断的患者样本在临床严重程度方面的差异特征。本研究对横断面、病例对照和队列研究的文献进行了系统回顾，其中以英语和西班牙语发表的BD或BPD患者样本与BD - BPD合并症样本进行了比较，研究对象为18至65岁的人群。那些考虑其他合并症患者样本的研究被排除在外。结果共纳入12项研究，共纳入4246例男女患者。与单一诊断者相比，双相障碍和BPD的合并症表现出更高的自杀率、抑郁发作和躁狂/轻躁狂、攻击性、愤怒和敌意、住院率、功能恶化和症状严重程度，特别是与无此症状的患者相比，双相障碍和BPD的合并症对临床病程的影响更大。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Revista Colombiana de Psiquiatria Medicine-Psychiatry and Mental Health

CiteScore

2.50

自引率

0.00%

发文量

期刊介绍： Revista Colombiana de Psiquiatría (RCP) is a quarterly official publication of Colombian Psychiatry Association (March, June, September and December) and its purpose is to spread different the knowledge models that currently constitute the theoretical and practical body of our specialty. Psychiatrists, psychiatric residents, non psychiatric physicians, psychologists, philosophers or other health professionals or persons interested in this area can take part in the magazine. This journal publishes original works, revision or updating articles, case reports of all psychiatry and mental health areas, epistemology, mind philosophy, bioethics and also articles about methodology of investigation and critical reading.