An insight on the different synthetic routes for the facile synthesis of O/S-donor carbamide/thiocarbamide analogs and their miscellaneous pharmacodynamic applications

IF 2.1 3区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY
Faiza Asghar , Bushra Shakoor , Babar Murtaza , Ian S. Butler
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Abstract

This review provides comprehensive data on the recent advances in various preparative methods of carbamides/thiocarbamides possessing oxygen/sulfur donor sites and their biological relevance. This review summarizes the numerous protocols for synthesizing carbamides/thiocarbamides from isocyanides, amidines, or amines, carbamates, alkyl halides are described, and also their green synthesis thus considerably expanding the scope of carbamides/thiocarbamides chemistry. Due to its tunable physicochemical and structural features, carbamide/thiocarbamide-based scaffolds are widely used in medicinal chemistry. Nowadays, protein kinase inhibitors are the topic of interest for several drug development initiatives in the pharmaceutical industry, because genetic changes such as mutations, overexpression, translocations, and dysregulation are all involved in the pathogenesis of many disorders. In this review, the compounds comprising carbamide/thiocarbamide pharmacophore have significant efficacy in comparison with the typical antibiotics against many bacterial strains which cause nosocomial infections and have acquired resistance to numerous medicines in the treatment of bacterial infections as well as a variety of ageing-related health issues such as cancer, antioxidants to inhibit uncontrolled growth of cells in the biological system, antifungal agents to inhibit the fungus growth, and neurological dysfunction have been described.

O/S供体氨基酰胺/硫代氨基酰胺类似物的不同合成路线及其各种药效学应用
摘要本文综述了具有氧/硫给体位点的酰胺/硫代酰胺的各种制备方法及其生物学相关性的最新进展。本文综述了由异氰酸酯、脒或胺、氨基甲酸酯、烷基卤化物合成氨基甲酸酯/硫代氨基酰胺的众多方案,以及它们的绿色合成,从而大大扩大了氨基甲酸酯和硫代氨基酰胺化学的范围。由于其可调的物理化学和结构特征,基于氨基甲酰胺/硫代氨基甲酰胺的支架在药物化学中得到了广泛应用。如今,蛋白激酶抑制剂是制药行业中几项药物开发计划感兴趣的主题,因为突变、过表达、易位和失调等基因变化都参与了许多疾病的发病机制。在这篇综述中,与典型的抗生素相比,包含氨基甲酰胺/硫代氨基甲酰胺药效团的化合物对许多引起医院感染的细菌菌株具有显著的疗效,并且在治疗细菌感染以及各种与年龄相关的健康问题如癌症、,已经描述了抑制生物系统中细胞不受控制生长的抗氧化剂、抑制真菌生长的抗真菌剂以及神经功能障碍。图形摘要
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来源期刊
Journal of Sulfur Chemistry
Journal of Sulfur Chemistry CHEMISTRY, MULTIDISCIPLINARY-
CiteScore
4.10
自引率
9.10%
发文量
38
审稿时长
6-12 weeks
期刊介绍: The Journal of Sulfur Chemistry is an international journal for the dissemination of scientific results in the rapidly expanding realm of sulfur chemistry. The journal publishes high quality reviews, full papers and communications in the following areas: organic and inorganic chemistry, industrial chemistry, materials and polymer chemistry, biological chemistry and interdisciplinary studies directly related to sulfur science. Papers outlining theoretical, physical, mechanistic or synthetic studies pertaining to sulfur chemistry are welcome. Hence the target audience is made up of academic and industrial chemists with peripheral or focused interests in sulfur chemistry. Manuscripts that truly define the aims of the journal include, but are not limited to, those that offer: a) innovative use of sulfur reagents; b) new synthetic approaches to sulfur-containing biomolecules, materials or organic and organometallic compounds; c) theoretical and physical studies that facilitate the understanding of sulfur structure, bonding or reactivity; d) catalytic, selective, synthetically useful or noteworthy transformations of sulfur containing molecules; e) industrial applications of sulfur chemistry; f) unique sulfur atom or molecule involvement in interfacial phenomena; g) descriptions of solid phase or combinatorial methods involving sulfur containing substrates. Submissions pertaining to related atoms such as selenium and tellurium are also welcome. Articles offering routine heterocycle formation through established reactions of sulfur containing substrates are outside the scope of the journal.
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