Cover Image: Salmonella Typhimurium manipulates macrophage cholesterol homeostasis through the SseJ-mediated suppression of the host cholesterol transport protein ABCA1 (Cellular Microbiology 08/2021)

IF 2.6 2区生物学 Q3 CELL BIOLOGY

Cellular Microbiology Pub Date : 2021-07-13 DOI:10.1111/cmi.13377

Adam R. Greene, Katherine A. Owen, James E. Casanova

引用次数: 0

Abstract

Salmonella Typhimurium induces accumulation of cholesterol in WT macrophages (top right) but not in the absence of the host kinase FAK (bottom left) or the bacterial effector protein SseJ (bottom right). For further details, readers are referred to the article by Greene et al. on p. e13329 of this issue.

Abstract Image

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封面图片：鼠伤寒沙门氏菌通过SseJ介导的对宿主胆固醇转运蛋白ABCA1的抑制来操纵巨噬细胞胆固醇稳态（细胞微生物学，2021年8月）

鼠伤寒沙门氏菌在WT巨噬细胞中诱导胆固醇积累(右上)，但在缺乏宿主激酶FAK(左下)或细菌效应蛋白SseJ(右下)的情况下不会。欲了解更多细节，请参阅本期e13329页Greene等人的文章。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cellular Microbiology 生物-微生物学

CiteScore

9.70

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： Cellular Microbiology aims to publish outstanding contributions to the understanding of interactions between microbes, prokaryotes and eukaryotes, and their host in the context of pathogenic or mutualistic relationships, including co-infections and microbiota. We welcome studies on single cells, animals and plants, and encourage the use of model hosts and organoid cultures. Submission on cell and molecular biological aspects of microbes, such as their intracellular organization or the establishment and maintenance of their architecture in relation to virulence and pathogenicity are also encouraged. Contributions must provide mechanistic insights supported by quantitative data obtained through imaging, cellular, biochemical, structural or genetic approaches.