Evaluation of Synergistic Effect of Combined Treatment with Linalool and Colistin on Multidrug-Resistant Acinetobacter baumannii to Expand Candidate for Therapeutic Option

Abstract

Background: Acinetobacter baumannii infection is a significant health problem worldwide due to increased drug resistance. The limited antimicrobial A total of 51 strains of A. baumannii clinical isolates, consisting of 10 MDRAB and XDRAB were tested. We determined the minimum inhibitory concentration (MIC) of linalool for the test strains using the broth microdilution method and searched for interactions using the time-kill assay. time-kill assay linalool colistin rate of synergy synergy criteria 2), low rate of indifference (7.8%), a of bactericidal activity (74.5%) the 51 clinical isolates baumannii. The synergy rates for the linalool and colistin combination against MDRAB and XDRAB were 96% 92.1%, respectively. No antagonism was observed for the linalool and colistin combination. Conclusions: The combination of linalool and colistin showed a high synergy rate, which may be beneficial for controlling MDRAB infections. Therefore, this combination is a good candidate for in vivo studies to assess its efficacy in the treatment of MDRAB infections.