Metabolomics in environmental toxicology: Applications and challenges

IF 11.1 2区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Environmental Analytical Chemistry Pub Date : 2022-06-01 DOI:10.1016/j.teac.2022.e00161

Carmen Bedia

{"title":"Metabolomics in environmental toxicology: Applications and challenges","authors":"Carmen Bedia","doi":"10.1016/j.teac.2022.e00161","DOIUrl":null,"url":null,"abstract":"<div><p>Metabolomics is a discipline aiming to characterize the presence of metabolites in biological matrices under specific conditions. In recent years, metabolomics has increasingly been used in environmental research to explore the metabolic changes in humans and organisms under diverse environmental exposures, mainly chemical pollutants. Hence, metabolomics has become a key tool in exposome studies, to explore the biological effects at molecular level exerted by xenobiotics. To understand the biological mechanisms triggered by specific chemical compounds, the combination of metabolomics with information about the presence of xenobiotics in the biological samples (xenometabolome), and other molecular information obtained from omics technologies (e.g. transcriptomics, proteomics) is crucial, both in exposome studies, and adverse outcome pathways (AOPs) development.</p><p>This review aims to describe the main applications of metabolomics in the assessment of biological effects induced by chemical pollutants on ecosystems and human health, both in exposome studies and in laboratory-controlled assays. Different analytical aspects and recent analytical challenges are presented and discussed. Finally, the different opportunities and the current situation of metabolomics as a tool in chemical safety assessment for regulatory applications are reviewed.</p></div>","PeriodicalId":56032,"journal":{"name":"Trends in Environmental Analytical Chemistry","volume":null,"pages":null},"PeriodicalIF":11.1000,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214158822000083/pdfft?md5=6056691b7cd2897ee56c2766a935d51e&pid=1-s2.0-S2214158822000083-main.pdf","citationCount":"16","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Trends in Environmental Analytical Chemistry","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2214158822000083","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}

引用次数: 16

Abstract

Metabolomics is a discipline aiming to characterize the presence of metabolites in biological matrices under specific conditions. In recent years, metabolomics has increasingly been used in environmental research to explore the metabolic changes in humans and organisms under diverse environmental exposures, mainly chemical pollutants. Hence, metabolomics has become a key tool in exposome studies, to explore the biological effects at molecular level exerted by xenobiotics. To understand the biological mechanisms triggered by specific chemical compounds, the combination of metabolomics with information about the presence of xenobiotics in the biological samples (xenometabolome), and other molecular information obtained from omics technologies (e.g. transcriptomics, proteomics) is crucial, both in exposome studies, and adverse outcome pathways (AOPs) development.

This review aims to describe the main applications of metabolomics in the assessment of biological effects induced by chemical pollutants on ecosystems and human health, both in exposome studies and in laboratory-controlled assays. Different analytical aspects and recent analytical challenges are presented and discussed. Finally, the different opportunities and the current situation of metabolomics as a tool in chemical safety assessment for regulatory applications are reviewed.

查看原文本刊更多论文

代谢组学在环境毒理学中的应用和挑战

代谢组学是一门旨在表征特定条件下生物基质中代谢物存在的学科。近年来，代谢组学越来越多地应用于环境研究，以探索人类和生物在不同环境暴露下的代谢变化，主要是化学污染物。因此，代谢组学已成为暴露学研究的重要工具，在分子水平上探索外源物的生物学效应。为了了解特定化合物触发的生物学机制，代谢组学与生物样品中存在的异种生物的信息(异种代谢组学)以及从组学技术(如转录组学、蛋白质组学)获得的其他分子信息的结合在暴露研究和不良后果途径(AOPs)发展中都是至关重要的。本文综述了代谢组学在化学污染物对生态系统和人类健康的生物效应评估中的主要应用，包括暴露研究和实验室控制分析。不同的分析方面和最近的分析挑战提出和讨论。最后，综述了代谢组学作为一种监管应用的化学品安全评估工具的不同机会和现状。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Trends in Environmental Analytical Chemistry Chemistry-Analytical Chemistry

CiteScore

21.20

自引率

2.70%

发文量

审稿时长

44 days

期刊介绍： Trends in Environmental Analytical Chemistry is an authoritative journal that focuses on the dynamic field of environmental analytical chemistry. It aims to deliver concise yet insightful overviews of the latest advancements in this field. By acquiring high-quality chemical data and effectively interpreting it, we can deepen our understanding of the environment. TrEAC is committed to keeping up with the fast-paced nature of environmental analytical chemistry by providing timely coverage of innovative analytical methods used in studying environmentally relevant substances and addressing related issues.