The relationship between serum cystatin C levels and Hughes motor scale in Guillain-Barré syndrome

IF 1.2 4区医学 Q4 CLINICAL NEUROLOGY

Neurosciences Pub Date : 2022-07-01 DOI:10.17712/nsj.2022.3.20210126

Mengying Chen, Jinming Shi, Jiaxin Fan, Hong-Suo Sun, Q. Yao, Xiaodong Zhang, Shuang Du, Huiyang Qu, Yuxuan Cheng, Shuyin Ma, Meijuan Zhang, Shuqin Zhan

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引用次数: 0

Abstract

Objectives: To study the clinical features of Guillain–Barré syndrome (GBS) and the relationship between serum cystatin C (cysC) levels and Hughes motor scale (HMS) in GBS. Methods: One hundred and one GBS patients between January 2017 and January 2020 were reviewed retrospectively. Their epidemiological characteristics, clinical manifestations and auxiliary examinations were assessed. The HMS was used to measure the peak deficit. The influencing factors of GBS severity were analyzed by univariate and multivariate analyses. Results: The serum cysC levels were significantly higher in the severe group than in the mild group [0.98 (0.85-1.20) vs. 0.81 (0.76-0.95), p=0.004], and there was a positive correlation between serum cysC levels and HMS in GBS patients (r=0.376, p=0.001). On multivariate analysis, respiratory muscle palsy (p=0.003), time to peak deficit (p=0.017), serum cysC (p=0.045) and hyponatremia (p=0.015) were independent risk factors for a poor functional outcome (HMS>3). Combining serum cysC and respiratory muscle palsy was more valuable for assessing disease severity than respiratory muscle palsy alone (AUC 0.863 vs. 0.787, p=0.001). Conclusion: Serum cysC was an independent risk factor in GBS, and positively correlated with HMS. It might be used to assess the severity of GBS with other negative prognostic factors.

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Guillain-Barré综合征血清胱抑素C水平与Hughes运动量表的关系

目的：研究格林-巴利综合征（GBS）的临床特点及其血清胱抑素C（cysC）水平与休斯运动量表（HMS）的关系。方法：对2017年1月至2020年1月期间的111例GBS患者进行回顾性分析。对其流行病学特征、临床表现和辅助检查进行了评估。HMS用于测量峰值赤字。采用单因素和多因素分析法对GBS严重程度的影响因素进行分析。结果：重症组的血清cysC水平显著高于轻症组[0.98（0.85-1.20）vs.0.81（0.76-0.95），p=0.004]，GBS患者的血清cybc水平与HMS呈正相关（r=0.376，p=0.001），血清cysC（p=0.045）和低钠血症（p=0.015）是功能不良（HMS>3）的独立危险因素。与单纯呼吸肌麻痹相比，血清cysC和呼吸肌麻痹对评估疾病严重程度更有价值（AUC 0.863 vs.0.787，p=0.001）。结论：血清cysC是GBS的独立危险因素，与HMS呈正相关。它可能用于评估GBS的严重程度和其他负面预后因素。

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来源期刊

Neurosciences 医学-临床神经学

CiteScore

1.40

自引率

0.00%

发文量

审稿时长

4.5 months

期刊介绍： Neurosciences is an open access, peer-reviewed, quarterly publication. Authors are invited to submit for publication articles reporting original work related to the nervous system, e.g., neurology, neurophysiology, neuroradiology, neurosurgery, neurorehabilitation, neurooncology, neuropsychiatry, and neurogenetics, etc. Basic research withclear clinical implications will also be considered. Review articles of current interest and high standard are welcomed for consideration. Prospective workshould not be backdated. There are also sections for Case Reports, Brief Communication, Correspondence, and medical news items. To promote continuous education, training, and learning, we include Clinical Images and MCQ’s. Highlights of international and regional meetings of interest, and specialized supplements will also be considered. All submissions must conform to the Uniform Requirements.