Meningoencefalitis por Histoplasma capsulatum. Una complicación infrecuente de la histoplasmosis diseminada

Abstract

Histoplasmosis is a common endemic in the Americas, that is caused by the dimorphic fungi, Histoplasma capsulatum. Pulmonary involvement is the most frequent clinical presentation of the disease, but disseminated acute or subacute infection, with skin and oral mucosal lesions, can happen in association with impaired cellular immunity, particulary human immunodeficiency virus (HIV) infection. Central nervous system infection occurs in only 5% to 10% of patients with disseminated histoplasmosis. The most common clinical form is a subacute or chronic basal meningitis. The diagnosis should be considered in all patients with chronic lymphocytic meningitis in endemic regions.