Role of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in predicting carcinoma prostate (CaP) in patients with lower urinary tract symptoms and raised serum prostate-specific antigen (sr.PSA)

Q2 Medicine

Medical Journal Armed Forces India Pub Date : 2024-12-01 DOI:10.1016/j.mjafi.2023.03.001

Sejal Mehta , Mrunal Ketkar , D.K. Jain

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引用次数: 0

Abstract

Background

Carcinoma prostate (CaP) is second most common cancer and sixth leading cause of cancer-related mortality among men worldwide. Prostate-specific antigen (sr. PSA) levels are prostate specific, not cancer specific. Therefore, finding non-invasive novel markers that can detect clinically significant CaP for preventing unnecessary biopsies is needed. Relation between host inflammatory responses and tumour has been increasingly recognized in various carcinomas. Many follow-up studies used neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) with sr. PSA level for CaP detection in India. The present study explored the use of these biomarkers in predicting CaP in patients with lower urinary tract symptoms (LUTS).

Methods

This prospective observational analytical study included 220 patients who underwent prostate biopsy for LUTS and suspected CaP between 2019 and 2021. Pearson's correlation (r) was used to find association between various attributes. Receiver operating characteristic curve analysis was performed to determine cut-off values and find sensitivity, specificity, positive and negative predictive value of NLR and PLR. P-value <0.05 was considered statistically significant (α = 5%).

Results

Out of 263 patients, 43 were excluded. Among remaining 220 study patients, 166 had BPH and 54 CaP. Median values of NLR and PLR were significantly higher in CaP patients. There was a strong positive correlation noted between NLR, PLR, and CaP groups. Areas under receiver operating characteristic curve of NLR (p = 0.001) and PLR (p < 0.001) for predicting CaP were statistically significant, with cut-off values of >3.44 and > 165.96, respectively.

Conclusion

In present study, we found significant increase in NLR and PLR in CaP patients. These parameters could be useful as pre-prostate biopsy predictors of CaP and help avoid unnecessary biopsies.

查看原文本刊更多论文

中性粒细胞与淋巴细胞比率（NLR）和血小板与淋巴细胞比率在预测下尿路症状和血清前列腺特异性抗原（sr.PSA）升高患者前列腺癌（CaP）中的作用

前列腺癌（CaP）是世界范围内男性癌症相关死亡的第二大常见癌症和第六大主要原因。前列腺特异性抗原（sr. PSA）水平是前列腺特异性的，而不是癌症特异性的。因此，需要寻找无创的新型标记物来检测具有临床意义的CaP，以防止不必要的活检。宿主炎症反应与肿瘤之间的关系在各种癌症中得到越来越多的认识。在印度，许多后续研究使用中性粒细胞与淋巴细胞比率（NLR）和血小板与淋巴细胞比率（PLR）与sr PSA水平进行CaP检测。本研究探讨了这些生物标志物在下尿路症状（LUTS）患者中预测CaP的应用。方法本前瞻性观察性分析研究纳入了2019年至2021年间因LUTS和疑似CaP接受前列腺活检的220例患者。Pearson’s correlation (r)用于发现不同属性之间的关联。进行受试者工作特征曲线分析，确定截断值，寻找NLR和PLR的敏感性、特异性、阳性预测值和阴性预测值。p值<；0.05认为有统计学意义（α = 5%）。结果263例患者中43例被排除在外。在剩余的220例研究患者中，166例BPH和54例CaP。CaP患者NLR和PLR的中位数显著高于CaP患者。NLR、PLR和CaP组间存在显著正相关。NLR （p = 0.001）和PLR (p <；0.001)预测CaP有统计学意义，临界值为>；3.44和>；165.96,分别。结论本研究发现CaP患者NLR和PLR明显增高。这些参数可以作为前列腺活检前CaP的预测指标，并有助于避免不必要的活检。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medical Journal Armed Forces India Medicine-Medicine (all)

CiteScore

3.40

自引率

0.00%

发文量

206

期刊介绍： This journal was conceived in 1945 as the Journal of Indian Army Medical Corps. Col DR Thapar was the first Editor who published it on behalf of Lt. Gen Gordon Wilson, the then Director of Medical Services in India. Over the years the journal has achieved various milestones. Presently it is published in Vancouver style, printed on offset, and has a distribution exceeding 5000 per issue. It is published in January, April, July and October each year.