Towards modeling of phonation and its recovery in unilateral vocal fold paralysis by fluid-structure interaction.

IF 2.2 4区工程技术 Q3 PHARMACOLOGY & PHARMACY

Bioimpacts Pub Date : 2023-01-01 Epub Date: 2023-07-22 DOI:10.34172/bi.2023.23809

MohammadAmin Naseri, Seyed Esmail Razavi

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引用次数: 0

Abstract

Introduction: Vocal folds are responsible for sound generation. In unilateral vocal fold paralysis (UVFP), the recurrent laryngeal nerve, which controls the vocal folds, is paralyzed. Medialization laryngoplasty is a surgery in which an implant is inserted to push the paralyzed vocal fold to the centerline to recover phonation.

Methods: Here, a numerical simulation is used to calculate flow-related parameters to give insight into what happens in healthy and treated(implanted) vocal folds and their enhancement. In the present work, airflow over vocal folds is modeled considering fluid-structure interaction (FSI) and varying inlet pressure. The governing equations are discretized for fluid and solid domains and solved using the Galerkin finite element method. The boundary conditions for healthy and unilaterally paralyzed vocal folds were imposed to agree with real cases behavior.

Results: The results showed the effectiveness of medialization laryngoplasty in treating unilateral vocal fold paralysis concerning healthy vocal folds.

Conclusion: This simulation provided a better insight into treatment results for patient-specific cases.

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应用流体-结构相互作用模拟单侧声带麻痹的发声及其恢复

前言：声带负责声音的产生。在单侧声带麻痹（UVFP）中，控制声带的喉返神经瘫痪。内侧化喉成形术是一种插入植入物将瘫痪的声带推到中心线以恢复发音的手术。方法：在这里，使用数值模拟来计算与流量相关的参数，以深入了解健康和治疗（植入）声带中发生的情况及其增强。在本工作中，考虑到流体-结构相互作用（FSI）和不同的入口压力，对声带上方的气流进行了建模。对流体和固体区域的控制方程进行离散化，并使用Galerkin有限元方法求解。健康和单侧麻痹声带的边界条件是为了符合真实情况下的行为。结果：应用鼻中隔成形术治疗单侧声带麻痹的疗效与健康声带有关。结论：该模拟为患者特定病例的治疗结果提供了更好的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bioimpacts Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

4.80

自引率

7.70%

发文量

审稿时长

5 weeks

期刊介绍： BioImpacts (BI) is a peer-reviewed multidisciplinary international journal, covering original research articles, reviews, commentaries, hypotheses, methodologies, and visions/reflections dealing with all aspects of biological and biomedical researches at molecular, cellular, functional and translational dimensions.