GLOBAL DYNAMICS AND OPTIMAL CONTROL FOR A VECTOR-BORNE EPIDEMIC MODEL WITH MULTI-CLASS-AGE STRUCTURE AND HORIZONTAL TRANSMISSION

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-01-31 DOI:10.1142/s0218339023500109

Shuangshuang Liang, Shengfu Wang, Lin Hu, L. Nie

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Abstract

An age-structured vector-borne disease model with horizontal transmission is proposed and studied in this paper, where the incubation ages of both host and vector and the immunity age of host are also introduced to consider the effects of multi-class-age structure. The reproductive number [Formula: see text] is derived as a threshold value to determine the existence and stability of the disease-free and endemic steady states. Furthermore, by constructing suitable Lyapunov functionals, the global threshold dynamics of this model is established by [Formula: see text], that is, the disease-free equilibrium is globally asymptotically stable when [Formula: see text], while if [Formula: see text] the endemic equilibrium is globally asymptotically stable. In addition, considering the limited budget of the centers for disease control and prevention (CDC) in the process of disease control, we present an optimal control problem with a fixed total expenditure, and discuss the existence of the most control strategy for this disease. Finally, some numerical simulations are performed to support the theoretical results.

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一类具有多类结构和水平传播的媒介传染病模型的全局动力学和最优控制

本文提出并研究了一个具有水平传播的年龄结构的媒介传播疾病模型，其中引入了宿主和媒介的潜伏期以及宿主的免疫年龄，以考虑多类年龄结构的影响。生殖数[公式：见正文]是一个阈值，用于确定无病和地方病稳定状态的存在和稳定性。此外，通过构造合适的李雅普诺夫泛函，该模型的全局阈值动力学由[公式：见正文]建立，即当[公式：参见正文]时，无病平衡是全局渐近稳定的，而如果[公式：看正文]，地方病平衡是全球渐近稳定的。此外，考虑到疾病预防控制中心（CDC）在疾病控制过程中的有限预算，我们提出了一个固定总支出的最优控制问题，并讨论了该疾病存在的最控制策略。最后，进行了一些数值模拟以支持理论结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.