PATTERN OF ANTI EPILEPTIC DRUG ADVERSE EFFECT IN TERTIARY REFERRAL HOSPITAL

Malang Neurology Journal Pub Date : 2020-06-25 DOI:10.21776/ub.mnj.2020.006.02.6

Ria Damayanti, M. Husna, Yeni Quinta Mondiani, S. Kurniawan

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Abstract

Background: Epilepsy is a major chronic neurological problem in the world. The goal of epilepsy therapy is seizure-free and without side effects. The emergence of side effects in patients with epilepsy will be its limitations that can cause the failure of epilepsy therapy. Therefore, it is necessary to do a simple descriptive study, which illustrates the pattern of side effects of anti-epileptic drugs that occur in people with epilepsy, so that later clinicians are more alert and can take preventative measures. Objective: Knowing the pattern of side effects of antiepileptic drugs at the Neurology Outpatient Clinic dr. Saiful Anwar hospital. Methods: This research is an observational descriptive study. Samples were taken by filling the questionnaire at the Neurology Outpatient Clinic dr. Saiful Anwar hospital. Demographic data in this study will be presented in the frequency distribution table. Chi Square test is used to determine the relationship of demographic data, also the pattern of therapy with the side effects that arise. Results: 93 epilepsy patients were involved in the study. More than 40% of patients experience side effects. The most common side effects appear in idiopathic epilepsy (30.1%). Based on the duration of epilepsy, the most side effects appear in epilepsy duration> 10 years (17.2%). However, from the results of the influence test using chi square, there was no significant difference between the duration of epilepsy with the appearance of side effects, even the type of epilepsy (p-value> 0.05). 28 patients who experience side effects, appear after the duration of use of AED 1 - 5 years. It was found that the duration of AED uses affected the emergence of side effects (p-value <0.05). Conclusion: Side effects occur in patients taking anti-epileptic drugs, and are related to the duration of drug use. This data can be used to increase the awareness of clinicians related to the emergence of side effects in patients who consume AED.

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三级转诊医院抗癫痫药物不良反应模式

背景:癫痫是世界范围内主要的慢性神经系统疾病。癫痫治疗的目标是无癫痫发作和无副作用。癫痫患者出现的副作用将是其局限性，可能导致癫痫治疗失败。因此，有必要做一个简单的描述性研究，说明抗癫痫药物在癫痫患者身上发生的副作用规律，以便后期临床医生更加警惕，采取预防措施。目的:了解安华医院神经内科门诊抗癫痫药物的不良反应规律。方法:本研究为观察性描述性研究。样本是在Saiful Anwar医生医院的神经病学门诊通过填写问卷获得的。本研究的人口统计数据将以频率分布表的形式呈现。卡方检验用于确定人口统计数据的关系，以及治疗模式与出现的副作用的关系。结果:共纳入93例癫痫患者。超过40%的患者会出现副作用。最常见的副作用出现在特发性癫痫(30.1%)。从癫痫持续时间来看，癫痫持续时间为10 ~ 10年的患者出现的副作用最多(17.2%)。然而，从卡方影响检验的结果来看，癫痫持续时间与副作用的出现，甚至癫痫类型之间均无显著差异(p值> 0.05)。有28例患者在使用AED 1 ~ 5年后出现副作用。使用AED的时间长短影响不良反应的发生(p值<0.05)。结论:抗癫痫药物的不良反应与用药时间有关。这些数据可用于提高临床医生对使用AED的患者出现的副作用的认识。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Malang Neurology Journal

自引率

0.00%

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审稿时长

48 weeks