Steven Posniak , Johnson H.Y. Chung , Xiao Liu , Payal Mukherjee , Gordon G. Wallace
{"title":"The importance of elastin and its role in auricular cartilage tissue engineering","authors":"Steven Posniak , Johnson H.Y. Chung , Xiao Liu , Payal Mukherjee , Gordon G. Wallace","doi":"10.1016/j.bprint.2023.e00276","DOIUrl":null,"url":null,"abstract":"<div><p><span><span><span>Cartilage regeneration remains a challenge in the field of regenerative medicine. Advances in cartilage regeneration would greatly benefit patients requiring </span>reconstructive surgeries<span><span><span> as a result of injury or congenital deformities. Injury can be of the form of trauma or congenital deformities such as </span>microtia, where afflicted children are born with a deformed ear and consequently often experience self-confidence and other psychological issues. Prevalence rates vary among regions but may be as high as 17.4 per 10,000 </span>births<span>. Current treatments for people with this condition are inadequate, with patients requiring multi-stage surgeries or expensive synthetic replacements. There is promise that damaged or missing </span></span></span>elastic cartilage<span><span><span> could be replaced using biofabrication techniques and technologies. Biofabrication employs cell-laden, tissue compatible and </span>biodegradable scaffolds<span> to then be transplanted into a patient and regenerate the naturally missing tissue that conforms to the defect. Elastin is a highly insoluble structural protein and is found in the </span></span>extracellular matrix (ECM) of </span></span>elastic tissues<span>; where it provides the tissues with their elasticity. There is currently no reported literature of direct investigation of the functional role of elastin fibres in auricular cartilage. This review will therefore explore the potential of regenerating auricular cartilage using 3D techniques and technologies with the goal to incorporate or facilitate the production of the elastin content of native cartilage.</span></p></div>","PeriodicalId":37770,"journal":{"name":"Bioprinting","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioprinting","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2405886623000192","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Computer Science","Score":null,"Total":0}
引用次数: 0
Abstract
Cartilage regeneration remains a challenge in the field of regenerative medicine. Advances in cartilage regeneration would greatly benefit patients requiring reconstructive surgeries as a result of injury or congenital deformities. Injury can be of the form of trauma or congenital deformities such as microtia, where afflicted children are born with a deformed ear and consequently often experience self-confidence and other psychological issues. Prevalence rates vary among regions but may be as high as 17.4 per 10,000 births. Current treatments for people with this condition are inadequate, with patients requiring multi-stage surgeries or expensive synthetic replacements. There is promise that damaged or missing elastic cartilage could be replaced using biofabrication techniques and technologies. Biofabrication employs cell-laden, tissue compatible and biodegradable scaffolds to then be transplanted into a patient and regenerate the naturally missing tissue that conforms to the defect. Elastin is a highly insoluble structural protein and is found in the extracellular matrix (ECM) of elastic tissues; where it provides the tissues with their elasticity. There is currently no reported literature of direct investigation of the functional role of elastin fibres in auricular cartilage. This review will therefore explore the potential of regenerating auricular cartilage using 3D techniques and technologies with the goal to incorporate or facilitate the production of the elastin content of native cartilage.
期刊介绍:
Bioprinting is a broad-spectrum, multidisciplinary journal that covers all aspects of 3D fabrication technology involving biological tissues, organs and cells for medical and biotechnology applications. Topics covered include nanomaterials, biomaterials, scaffolds, 3D printing technology, imaging and CAD/CAM software and hardware, post-printing bioreactor maturation, cell and biological factor patterning, biofabrication, tissue engineering and other applications of 3D bioprinting technology. Bioprinting publishes research reports describing novel results with high clinical significance in all areas of 3D bioprinting research. Bioprinting issues contain a wide variety of review and analysis articles covering topics relevant to 3D bioprinting ranging from basic biological, material and technical advances to pre-clinical and clinical applications of 3D bioprinting.