New Recommendations for T2D Management: Beneficial Impact of Exerkines on Pancreatic ?-Cells Function and Glucose Homeostasis in Skeletal Muscle

Abstract

Nowadays, physical activity is strongly considered as an effective strategy in both preventing and treating type 2 diabetes (T2D) [1,2]. Indeed, it is well established that exercises improve β-cell insulin signaling, insulin secretion, prevent pancreatic β-cell failure and impacts glucose homeostasis regulation in T2D patients [3-8]. Moreover, exercise has clearly shown to improve the peripheral insulin sensitivity in T2D patients and to have a beneficial effect on insulin resistance [9-12]. The improvement of peripheral insulin sensitivity in T2D patients and the beneficial effect on insulin resistance by the exercise have been widely documented. For these Abstract