Expresión de enzimas relacionadas con la síntesis de poliaminas en mucosa intestinal de cerdos recién destetados

Abstract

The weaning stress can modify the intestinal health of piglets; at this period arginine become essential, because its role at the polyamine synthesis, that are important to maintain cell viability and proliferation in the intestinal epithelium. The expression of enzymes argininosuccinate synthetase (ASS) and spermine/spermidine acetyl transferase (SSAT), associated to arginine and polyamines synthesis on mucosae of small intestine from weaned pigs, was analyzed. Twenty-four pigs, weaned at 28 days of age were slaughtered at 0, 3, 7 and 14 days post-weaning. Mucosal samples were collected of duodenum, jejunum and ileum, to analyze the relative expression of ASS and SSAT. The ASS expression in duodenum increased at d3 (P 0.10). In general, the expression of ASS and SSAT was higher in ileum compared to duodenum and jejunum (P<0.05). In conclusion postweaning stress increases the expression of ASS and SSAT in intestinal mucosa from piglets in the first three days after weaning.