The Effect of High Intensity Intermittent Training (HIIT) on GLP-1R Expression in Pancreas Tissue and Serum Insulin of Male Wistar Rats with Type 2 Diabetes Mellitus

Abstract

ype 2 diabetes mellitus (T2DM) often is related to dysfunction of β-cells of pancreas and lower level of insulin secretion. Reduced level of insulin secretion is often associated with increased insulin resistance, increased release of glucosedependent glucagon from liver deposits, and a rapid increase in glucose uptake from nutrients (1). Based on the presented laboratory evidence, destruction of pancreatic β-cells is a hallmark of T2DM, which is related to a reduction in the synthesis and secretion of insulin. The mentioned destruction is also connected to dysfunction of incretin hormones. Clinical studies revealed that the rate of apoptosis in β-cells is faster than the T 1. Assistant Professor of Exercise Physiology, Qom University of Technology, Qom, Iran. 2. Assistant Professor, Department of Exercise Physiology, Faculty of Humanities Sciences, Islamic Azad University, Saveh Branch, Saveh, Iran.