Detection of the characteristic magnetic signal of paclitaxel and its application in the inhibition of glioma cells

IF 6.3 3区综合性期刊 Q1 Multidisciplinary

Fundamental Research Pub Date : 2025-09-01 DOI:10.1016/j.fmre.2022.09.036

Yinhui Deng , Quan Tao , Qisheng Tang , Yinlong Liu , Hui Dong , Zhifeng Shi , Xiaoming Xie , Weiqi Wang , Liangfu Zhou , Jinhua Yu

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Abstract

Glioma, a type of brain tumor, is one of the most challenging cancers for human beings due to its genetic heterogeneity, high recurrence rate and difficulty of effective treatment. To explore a novel treatment method for glioma, a scientific hypothesis was proposed that a chemical substance or biological agent may generate a characteristic magnetic signal, and this signal is the fundamental reason that the chemical substance or biological agent works for cancer treatment. Based on this hypothesis, a superconducting quantum interference device (SQUID) using the stochastic resonance (SR) method was established, and the characteristic magnetic signal of paclitaxel was detected and clearly visualized for the first time. Then, cell experimental results demonstrated that the detected characteristic magnetic signal of paclitaxel was as effective as paclitaxel for the inhibition of glioma cells. Our study suggested that the application of paclitaxel's characteristic magnetic signal might provide an ideal treatment direction for glioma patients due to its lack of side effects, high focusable penetration and effectiveness.

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紫杉醇特征磁信号的检测及其在抑制胶质瘤细胞中的应用

胶质瘤是脑肿瘤的一种，由于其遗传异质性、高复发率和难以有效治疗，是人类最具挑战性的癌症之一。为了探索治疗胶质瘤的新方法，提出了一种科学假设，即某种化学物质或生物制剂可能会产生一种特征磁信号，这种信号是该化学物质或生物制剂治疗肿瘤的根本原因。基于这一假设，利用随机共振（SR）方法建立了超导量子干涉器件（SQUID），首次检测并清晰地显示了紫杉醇的特征磁信号。然后，细胞实验结果表明，检测到的紫杉醇特征磁信号对胶质瘤细胞的抑制作用与紫杉醇一样有效。本研究提示，利用紫杉醇特有的磁信号治疗胶质瘤具有副作用小、可聚焦穿透力强、疗效好等优点，可能为胶质瘤患者提供一个理想的治疗方向。

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