Protective Effect of Acetyl L-Carnitine on Rat Spermatogenesis Defects Induced by Lead Acetate

mjl@ lnbr ll`lwm lbyTry@ Pub Date : 2023-06-01 DOI:10.37940/ajvs.2023.16.1.9

A. Ibrahim, Enas Osama Husain.

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Abstract

In this study the influences of the ameliorative effects of Acetyl-L-carnitine, when exposed to lead acetate on functional aspects in spermatogenesis process in the testes of albino male rats, studied, 24 male albino rats weight 178-250 g were randomly distributed into four groups, 6 rats in each, the control group received distilled water orally, Treatment 1 lead acetate group received 10mgkg body weight orally, Treatment 2 acetyl L-carnitine(ALCAR) group received 100mgkg body weight orally, and Treatment 3 lead acetate and acetyl L-carnitine group received 10mgkg body weight and 100mgkg body weight orally respectively. After the end of the experiment the weight of sexual organs were taken, in addition, the total sperm count number, and percentage of dead, live, with abnormal spermatozoa also have been calculated. Results showed that the total sperm count in the lead acetate group was decreased compared with the control and ALCAR groups. The lead acetate with ALCAR showed an increase in total sperm count and live sperm percentage in comparison with control and ALCAR groups. Dead and abnormal sperm percentage increased in the lead acetate group and in lead with ALCAR groups in compared with control and ALCAR grou

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乙酰左旋肉碱对醋酸铅致大鼠精子发生缺陷的保护作用

在本研究中，研究了乙酸铅对白化雄性大鼠睾丸精子发生过程中功能方面的影响，将24只体重178-250g的雄性白化大鼠随机分为四组，每组6只，对照组口服蒸馏水，治疗1醋酸铅组口服10mgmg体重，治疗2乙酰左旋肉碱（ALCAR）组口服100mgg体重，治疗3醋酸铅和乙酰左旋肉碱组分别口服10mgg体重和100mgg体重。实验结束后，测量性器官的重量，此外，还计算了精子总数，以及死亡、存活和异常精子的百分比。结果显示，与对照组和ALCAR组相比，醋酸铅组的精子总数有所下降。与对照组和ALCAR组相比，ALCAR组的醋酸铅显示总精子数和活精子百分比增加。与对照和ALCAR组相比，醋酸铅组和ALCAR铅组的死亡和异常精子百分比增加

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