Epidemiology of Celiac Disease in Northern Morocco in 2018–2021: A Descriptive Cross-Sectional Study

IF 0.4 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Maroua Haddadi, I. Mellouki, Yousra Benmakhlouf, A. Diakité, Aymane Khaili, S. Barrijal, Haiat Essalmani
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Abstract

Celiac disease is an autoimmune disease caused by gluten. This retrospective cross-sectional study with descriptive and analytical aims was conducted over three years, from 2018 to 2021. The participants were 280 patients diagnosed with celiac disease registered in the Gluten Intolerant and Allergic Association of the North in the Tangier-Tetouan-Al Hoceima region. The prevalence and incidence of celiac disease in this region were 1/135 and 1/253, respectively. The average age was 21.18 ± 1.13, and the first symptoms appeared between 10 and 25 years. The data showed a female predominance of 68% versus 32% for males, with a male/female sex ratio of 0.45. The clinical signs of celiac disease manifested more in gastrointestinal symptoms. This study obtained data on 22.6% of microcytic hypochromic anemia patients and 40.7% of Helicobacter pylori infections. In addition to celiac disease, the patients showed other pathologies with different rates: repeated spontaneous abortions (2.14%), type 1 diabetes mellitus (1.42%), autism (1.42%), dermatitis herpetiformis (0.72%), cancer(0.72%), and epilepsy (0.35%). Serologically, anti-transglutaminase antibodies were positive in 47.2% of patients. Analyses of histological data from intestinal biopsies from 141 patients were positive in 50.8% of patients. There was a minor correlation between the serological profile and the degree of atrophy.
2018-2021年摩洛哥北部乳糜泻流行病学:一项描述性横断面研究
乳糜泻是一种由麸质引起的自身免疫性疾病。这项具有描述性和分析性目的的回顾性横断面研究从2018年到2021年进行了三年。参与者是在丹吉尔-得土安-胡塞马地区北部麸质不耐受和过敏协会登记的280名被诊断患有乳糜泻的患者。该地区乳糜泻患病率和发病率分别为1/135和1/253。平均年龄21.18±1.13岁,首次发病年龄在10 ~ 25岁之间。数据显示,女性占68%,男性占32%,男女性别比为0.45。乳糜泻的临床症状多表现在胃肠道症状。本研究获得了22.6%的小细胞性低色素贫血患者和40.7%的幽门螺杆菌感染患者的数据。除乳糜泻外,患者还表现出不同比例的其他病理:反复自然流产(2.14%)、1型糖尿病(1.42%)、自闭症(1.42%)、疱疹样皮炎(0.72%)、癌症(0.72%)、癫痫(0.35%)。血清抗谷氨酰胺酶抗体阳性占47.2%。141例患者的肠道活检组织学数据分析为阳性,50.8%的患者呈阳性。血清学特征与萎缩程度之间有轻微的相关性。
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来源期刊
Kesmas-National Public Health Journal
Kesmas-National Public Health Journal PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-
CiteScore
1.70
自引率
0.00%
发文量
39
审稿时长
10 weeks
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