Anesthetic gas consumption with target-controlled administration versus a semi-closed circle system with automatic end-tidal concentration control in an artificial lung model

IF 3 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

Medical Gas Research Pub Date : 2022-04-17 DOI:10.4103/2045-9912.337991

M. Bellgardt, V. Vinnikov, A. Georgevici, Livia Procopiuc, T. Weber, A. Meiser, J. Herzog-Niescery, D. Drees

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Abstract

The use of volatile anesthetics as sedatives in the intensive care unit is relevant to the patient's outcome. We compared anesthetic gas consumption of the conventional semi-closed Aisys CS™ with the MIRUS™ system, which is the first anesthetic gas reflector system that can administer desflurane in addition to isoflurane and sevoflurane. We connected an artificial lung model to either a MIRUS™ system and a Puritan Bennett™ 840 ventilator or an Aisys CS™ anesthesia machine. We found that consumption of 0.5% isoflurane, which corresponds to the target concentration 0.5 MAC, was averaged to 2 mL/h in the MIRUS™ system, which is identical to the Aisys CS™ at a fresh gas flow (FGF) of 1.0 L/min. MIRUS™ consumption of 1% sevoflurane was averaged to 10 mL/h, which corresponds to 8.4 mL/h at FGF 2.5 L/min. The MIRUS™ system consumed 3% or 4% desflurane at an average of 13.0 mL/h or 21.3 mL/h, which is between the consumption at 1.0 L/min and 2.5 L/min FGF. Thus, the MIRUS™ system can effectively deliver volatile anesthetics in clinically relevant concentrations in a similar rate as a conventional circular breathing system at FGFs between 1.0 L/min and 2.5 L/min.

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人工肺模型中目标控制给药的麻醉气体消耗与自动潮气末浓度控制的半闭环系统

在重症监护室使用挥发性麻醉剂作为镇静剂与患者的预后有关。我们比较了传统的半封闭Aisys CS的麻醉气体消耗™ 与MIRUS™ 该系统是第一个除异氟烷和七氟醚外还可以使用地氟醚的麻醉气体反射系统。我们将人工肺模型连接到MIRU™ 制度与清教徒Bennett™ 840呼吸机或Aisys CS™ 麻醉机。我们发现，在MIRUS中，0.5%异氟烷的消耗量（相当于目标浓度0.5MAC）平均为2mL/h™ 系统，与Aisys CS相同™ 新鲜气体流量（FGF）为1.0L/min。米鲁斯™ 1%七氟醚的消耗量平均为10mL/h，相当于FGF为2.5L/min时的8.4mL/h。MIRUS™ 系统以13.0 mL/h或21.3 mL/h的平均消耗量消耗3%或4%的地氟醚，介于1.0 L/min和2.5 L/min FGF的消耗量之间。因此，MIRUS™ 该系统可以在1.0L/min和2.5L/min之间的FGF下以与传统循环呼吸系统相似的速率有效地递送临床相关浓度的挥发性麻醉剂。

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来源期刊

Medical Gas Research MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

5.10

自引率

13.80%

发文量

期刊介绍： Medical Gas Research is an open access journal which publishes basic, translational, and clinical research focusing on the neurobiology as well as multidisciplinary aspects of medical gas research and their applications to related disorders. The journal covers all areas of medical gas research, but also has several special sections. Authors can submit directly to these sections, whose peer-review process is overseen by our distinguished Section Editors: Inert gases - Edited by Xuejun Sun and Mark Coburn, Gasotransmitters - Edited by Atsunori Nakao and John Calvert, Oxygen and diving medicine - Edited by Daniel Rossignol and Ke Jian Liu, Anesthetic gases - Edited by Richard Applegate and Zhongcong Xie, Medical gas in other fields of biology - Edited by John Zhang. Medical gas is a large family including oxygen, hydrogen, carbon monoxide, carbon dioxide, nitrogen, xenon, hydrogen sulfide, nitrous oxide, carbon disulfide, argon, helium and other noble gases. These medical gases are used in multiple fields of clinical practice and basic science research including anesthesiology, hyperbaric oxygen medicine, diving medicine, internal medicine, emergency medicine, surgery, and many basic sciences disciplines such as physiology, pharmacology, biochemistry, microbiology and neurosciences. Due to the unique nature of medical gas practice, Medical Gas Research will serve as an information platform for educational and technological advances in the field of medical gas.