Zinc and its role in vitamin D function

IF 2.1 Q3 PHYSIOLOGY
Ashton Amos, Mohammed S. Razzaque
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引用次数: 11

Abstract

Zinc is an essential mineral with an important relationship with vitamin D. Studies have found that reduced blood zinc levels could predict vitamin D deficiency in adolescent girls, while zinc supplementation increased vitamin D levels in postmenopausal women. In vitro studies using human peritoneal macrophages have found that zinc induced the release of calcitriol (1,25-dihydroxycholecalciferol). Zinc also acts as a cofactor for vitamin D functions, as the transcriptional activity of vitamin D-dependent genes relies on zinc to exert pleiotropic functions, including mineral ion regulation. Vitamin D could also induce zinc transporters to regulate zinc homeostasis. Together, zinc and vitamin D in adequate concentrations help maintain a healthy musculoskeletal system and beyond; however, deficiency in either of these nutrients can result in various disorders affecting almost all body systems. This brief article will focus on the role of zinc in vitamin D functions.

锌及其在维生素D功能中的作用
锌是一种必需的矿物质,与维生素D有着重要的关系。研究发现,血液中锌水平的降低可以预测青春期女孩缺乏维生素D,而补充锌可以提高绝经后妇女的维生素D水平。利用人腹膜巨噬细胞进行的体外研究发现,锌诱导骨化三醇(1,25-二羟基胆骨化醇)的释放。锌还作为维生素D功能的辅助因子,因为维生素D依赖基因的转录活性依赖于锌来发挥多效性功能,包括矿物质离子调节。维生素D还可以诱导锌转运蛋白调节锌的体内平衡。足够浓度的锌和维生素D一起有助于维持健康的肌肉骨骼系统和其他系统;然而,缺乏这两种营养素中的任何一种都会导致影响几乎所有身体系统的各种疾病。这篇简短的文章将集中讨论锌在维生素D功能中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.20
自引率
0.00%
发文量
0
审稿时长
62 days
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