Acupoint combinations used for treatment of Alzheimer's disease: A data mining analysis

IF 2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Traditional Chinese Medicine Pub Date : 2018-12-15 DOI:10.1016/S0254-6272(18)30995-6

Yu Chaochao , Wang Li , Kong Lihong , Shen Feng , Ma Chaoyang , Du Yanjun , Zhou Hua

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引用次数: 19

Abstract

OBJECTIVE

To identify the acupoint combinations used in the treatment of Alzheimer's disease (AD).

METHODS

The clinical literature regarding acupuncture and moxibustion for AD was searched and collected from databases including Chinese Biomedical Medicine, China National Knowledge Infrastructure, Wanfang Database and PubMed. The database of acupuncture and moxibustion prescriptions for AD was established by using Excel software so as to conduct the descriptive analysis, association analysis on the data.

RESULTS

Baihui (GV 20), Sishencong (EX-HN 1), Shenmen (HT 7), Zusanli (ST 36), Neiguan (PC 6), Fengchi (GB 20), Taixi (KI 3), Dazhui (GV 14), Shenshu (BL 23), Sanyinjiao (SP 6), Shenting (GV 24), Fenglong (ST 40), Xuanzhong (GB 39), Shuigou (GV 26) and Taichong (LR 3) were of higher frequency in the treatment of AD with acupnucture and moxibustion. Most acupoints were selected from the Governor Vessel. The commonly used acupoints were located on the head, face, neck and lower limbs. The combination of the local acupoints with the distal ones was predominated. The crossing points among the specific points presented the advantage in the treatment. The association analysis indicated that the correlation among Fengchi (GB 20)-Baihui (GV 20) was the strongest, followed by combinations of Dazhui (GV 14)-Baihui (GV 20), Shenshu (BL 23)- Baihui (GV 20) and Neiguan (PC 6)- Baihui (GV 20) and indicated the common rules of the clinical acupoint selection and combination for AD.

CONCLUSION

Our findings provide a reference for acupoints selection and combination for AD in clinical acupuncture practice.

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穴位组合治疗阿尔茨海默病:数据挖掘分析

目的探讨治疗阿尔茨海默病(AD)的腧穴组合。方法从中国生物医学数据库、中国国家知识基础设施数据库、万方数据库和PubMed数据库中检索和收集针灸治疗AD的临床文献。运用Excel软件建立AD针灸方剂数据库，对数据进行描述性分析、关联分析。结果百会(GV 20)、四神聪(EX-HN 1)、神门(HT 7)、足三里(ST 36)、内关(PC 6)、风池(gb20)、太溪(KI 3)、大椎(GV 14)、肾疏(b23)、三阴交(SP 6)、神汀(GV 24)、凤龙(ST 40)、宣中(gb39)、水沟(GV 26)、太冲(lr3)是针灸治疗AD的高发部位。大多数穴位选自督脉。常用穴位位于头部、面部、颈部和下肢。以局部穴位与远端穴位相结合为主。特异点之间的交点在处理中表现出优势。关联分析显示风池(gb20)-百会(gv20)的相关性最强，大椎(gv14)-百会(gv20)、肾疏(b23)-百会(GV 20)、内关(pc6)-百会(GV 20)的相关性其次，提示了AD临床中西医结合的一般规律。结论本研究结果可为临床针灸治疗AD的取穴与配合提供参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Traditional Chinese Medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-

CiteScore

2.40

自引率

3.80%

发文量

32269

审稿时长

2 months

期刊介绍： Journal of Traditional Chinese Medicine（JTCM） is devoted to clinical and theortical research on the use of acupuncture and Oriental medicine. The main columns include Clinical Observations, Basic Investigations, Reviews, Questions and Answers, an Expert''s Forum, and Discussions of Clinical Cases. Its key topics include acupuncture and electro-acupuncture, herbal medicine, homeopathy, masseotherapy, mind-body therapies, palliative care, and other CAM therapies.