Can MELD score be a predictor of liver metastasis in colorectal cancer?

Journal of Clinical and Analytical Medicine Pub Date : 2018-11-01 DOI:10.4328/JCAM.5791

Ali Sapmaz

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引用次数: 0

Abstract

DOI: 10.4328/JCAM.5791 Received: 25.02.2018 Accepted: 14.04.2018 Published Online: 14.02.2018 Printed: 01.11.2018 J Clin Anal Med 2018;9(6): 474-7 Corresponding Author: Ali Sapmaz, Department of General Surgery, Numune Training and Research Hospital, 06100, Altındağ, Ankara, Turkey. T.: +90 3125084000 GSM: +905326454780 F.: +90 3123114340 E-Mail: dr_a_sapmaz@yahoo.com Abstract Aim: A significant number of patients with colorectal cancer (CRC) present with liver metastasis at initial diagnosis. The Model for End-Stage Liver Disease (MELD) score consists of three parameters including bilirubin, creatinine and International Normalized Ratio (INR), and is primarily used to rank the priority of patients awaiting liver transplantation. The aim of the study is to investigate the predictive value of MELD score for liver metastasis in patients with CRC. Material and Method: A total of 436 patients diagnosed as CRC were included in the study. The patients were divided into two groups: patients without liver metastasis and those with liver metastasis. The association between MELD score and presence of liver metastasis was investigated. Results: There were 256 (57.9%) males and 183 (41.1%) females, with an overall mean age of 64 years. Liver metastasis was found in 58 (13.2%) patients. Mean MELD score was found to be 8.88 in patients with hepatic metastasis whereas the patients without metastatic liver disease had a mean MELD score of 8.61 (p=0.015). Discussion: MELD score is significantly higher in patients with liver metastasis than in those without liver metastasis. Further studies may help to confirm this result and to determine a possible cut-off value of MELD score.

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MELD评分能否作为结直肠癌肝转移的预测指标?

DOI:10.4328/JCAM.5791接收日期：2018年2月25日接受日期：2018月4日在线发布日期：2018年底2月14日印刷日期：2018年年11月1日《临床分析医学杂志》；9（6）：474-7通讯作者：Ali Sapmaz，努穆恩训练研究医院普通外科，06100，Altındağ，土耳其安卡拉。电话：+90 3125084000电话：+905326454780传真：+90 312 3114340电子邮件：dr_a_sapmaz@yahoo.com摘要目的：大量癌症（CRC）患者在初次诊断时出现肝转移。终末期肝病模型（MELD）评分由三个参数组成，包括胆红素、肌酐和国际标准化比值（INR），主要用于对等待肝移植的患者的优先级进行排序。本研究的目的是探讨MELD评分对CRC患者肝转移的预测价值。材料和方法：本研究共纳入436例被诊断为CRC的患者。将患者分为两组：无肝转移患者和有肝转移患者。研究了MELD评分与肝转移之间的关系。结果：共有256名（57.9%）男性和183名（41.1%）女性，总体平均年龄为64岁。肝转移58例（13.2%）。肝转移患者的平均MELD评分为8.88，而无转移性肝病患者的平均MELD评分为8.61（p=0.015）。进一步的研究可能有助于证实这一结果，并确定MELD评分的可能截止值。

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Journal of Clinical and Analytical Medicine MEDICINE, GENERAL & INTERNAL-

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期刊介绍： The Annals of Clinical and Analytical Medicine is an international open-access journal containing peer-reviewed high-quality articles on clinical medicine in the areas of all research study types, reviews, and case reports. Our journal has become an important platform with the help of language support services, which make it easier for writers who have English as their second language to share their clinical experiences with the world.